DegronMD

Uniprot ID: Q8WU79

Source protein: Stromal membrane-associated protein 2

Source gene: SMAP2

Class: LIG_APCC_ABBA_1

Location: 245:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 79.2333

COIL: 0.8453

CONS_SCORE: 0.3251

DSS_SCORE: 0.5881

HELIX: 0.126

FCONS_SCORE: 1.1722

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G239C	TCGA-19-1389	GBM	TCGA	LNLFPE	LIG_APCC_ABBA_1	0.1667
p.P256L	DO225106	BRCA	ICGC	LNLFPE	LIG_APCC_ABBA_1	0.1667
p.M255I	DO8192	COAD	ICGC	LNLFPE	LIG_APCC_ABBA_1	0.1944
p.M240V	DO52184	LIHC	ICGC	LNLFPE	LIG_APCC_ABBA_1	0.6389
p.P252T	DO26743	LUSC	ICGC	LNLFPE	LIG_APCC_ABBA_1	0.2778
p.N246K	SIDM00101	Mesothelioma	GDSC	LNLFPE	LIG_APCC_ABBA_1	0.5806
p.N246K	H2591	pleura	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.5806
p.A235S	SIDM01191	Osteosarcoma	GDSC	LNLFPE	LIG_APCC_ABBA_1	0.0556
p.A235S	U-2-OS	bone	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.0556
p.M260T	BHY	upper_aerodigestive_tract	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.1667
p.M260T	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.1667
p.M260T	NCI-SNU-5	stomach	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.1667
p.N241K	H2591	pleura	COSMIC	LNLFPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU79	Stromal membrane-associated protein 2	LIG_APCC_ABBA_1	245:250	LNLFPE	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons