DegronMD - Q8WU79(SMAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G239C	TCGA-19-1389	GBM	TCGA	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1667
p.P301L	TCGA-55-7907	LUAD	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.6471
p.P301L	TCGA-EE-A20F	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.6471
p.G311V	TCGA-EE-A3AD	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.25
p.G302W	TCGA-FE-A237	THCA	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.6714
p.G311W	TCGA-FS-A1ZN	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.25
p.P256L	DO225106	BRCA	ICGC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1667
p.M255I	DO8192	COAD	ICGC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.T292I	DO52275	LIHC	ICGC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.M240V	DO52184	LIHC	ICGC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation blocking phosphorylation signal	0.6389
p.Q308H	DO23641	LUAD	ICGC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.7582
p.P252T	DO26743	LUSC	ICGC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.2778
p.P306S	SIDM00003	Melanoma	GDSC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.5641
p.P306S	M14	skin	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.5641
p.N246K	SIDM00101	Mesothelioma	GDSC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5806
p.N246K	H2591	pleura	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5806
p.A235S	SIDM01191	Osteosarcoma	GDSC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.A235S	U-2-OS	bone	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.V296A	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.1944
p.V296A	HEC-1	endometrium	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.1944
p.M260T	BHY	upper aerodigestive tract	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation substituting flanking lysine	0.1667
p.M260T	YT	haematopoietic and lymphoid tissue	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation substituting flanking lysine	0.1667
p.M260T	NCI-SNU-5	stomach	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation substituting flanking lysine	0.1667
p.N241K	H2591	pleura	COSMIC	LNLFPE	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.2222
p.P301S	M14	skin	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.6752

Kaplan plot for SMAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAP2

UniProt ID: Q8WU79

Entrez ID: 64744

Protein name: Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAP2 in