DegronMD

Uniprot ID: Q8WU79

Source protein: Stromal membrane-associated protein 2

Source gene: SMAP2

Class: DEG_SCF_FBW7_1

Location: 301:308

E3 ligase: FBXW7

DEGRON score: 0.936

ASA_SCORE: 66.625

COIL: 0.9373

CONS_SCORE: 0.3196

DSS_SCORE: 0.3382

HELIX: 0.0369

FCONS_SCORE: 1.1238

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P301L	TCGA-55-7907	LUAD	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	0.6471
p.P301L	TCGA-EE-A20F	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	0.6471
p.G311V	TCGA-EE-A3AD	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	0.25
p.G302W	TCGA-FE-A237	THCA	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	0.6714
p.G311W	TCGA-FS-A1ZN	SKCM	TCGA	PGVTPPNS	DEG_SCF_FBW7_1	0.25
p.T292I	DO52275	LIHC	ICGC	PGVTPPNS	DEG_SCF_FBW7_1	0.0833
p.Q308H	DO23641	LUAD	ICGC	PGVTPPNS	DEG_SCF_FBW7_1	0.7582
p.P306S	SIDM00003	Melanoma	GDSC	PGVTPPNS	DEG_SCF_FBW7_1	0.5641
p.P306S	M14	skin	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	0.5641
p.V296A	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGVTPPNS	DEG_SCF_FBW7_1	0.1944
p.V296A	HEC-1	endometrium	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	0.1944
p.P301S	M14	skin	COSMIC	PGVTPPNS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU79	Stromal membrane-associated protein 2	DEG_SCF_FBW7_1	301:308	PGVTPPNS	FBXW7	0.936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons