DegronMD

Uniprot ID: A6QL63

Source protein: Ankyrin repeat and BTB/POZ domain-containing protein BTBD11

Source gene: BTBD11

Class: LIG_APCC_ABBA_1

Location: 387:392

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9103

ASA_SCORE: 80.8667

COIL: 0.7462

CONS_SCORE: 0.2674

DSS_SCORE: 0.434

HELIX: 0.1615

FCONS_SCORE: 0.7814

RIG_SCORE: 0.7088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P393Q	TCGA-17-Z056	LUAD	TCGA	LNLHRD	LIG_APCC_ABBA_1	0.3056
p.L389I	TCGA-AG-3892	READ	TCGA	LNLHRD	LIG_APCC_ABBA_1	0.6063
p.L389I	DO36394	READ	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.6063
p.S386N	TCGA-FW-A3R5	SKCM	TCGA	LNLHRD	LIG_APCC_ABBA_1	0.3056
p.S386N	DO37406	SKCM	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.3056
p.E401K	TCGA-FW-A3R5	SKCM	TCGA	LNLHRD	LIG_APCC_ABBA_1	0.0833
p.E401K	DO37406	SKCM	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.0833
p.Q394H	TCGA-IB-7651	PAAD	TCGA	LNLHRD	LIG_APCC_ABBA_1	0.2778
p.Q394H	DO228971	LICA	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.2778
p.Q394H	DO46657	PAAD	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.2778
p.G379E	DO50439	ESAD	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.1111
p.D392E	DO223036	ESCA	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.5647
p.V380L	DO228952	LICA	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.1389
p.L381M	DO232224	PBCA	ICGC	LNLHRD	LIG_APCC_ABBA_1	0.1667
p.P399L	SIDM01060	Melanoma	GDSC	LNLHRD	LIG_APCC_ABBA_1	0.1389
p.P399L	ACH-000882	Skin Cancer	CCLE	LNLHRD	LIG_APCC_ABBA_1	0.1389
p.P399L	IGR-1	skin	COSMIC	LNLHRD	LIG_APCC_ABBA_1	0.1389
p.G402C	NCI-H1435	lung	COSMIC	LNLHRD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6QL63	Ankyrin repeat and BTB/POZ domain-containing protein BTBD11	LIG_APCC_ABBA_1	387:392	LNLHRD	APC,CDC20,FZR1	0.9103	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons