DegronMD

Uniprot ID: O75553

Source protein: Disabled homolog 1

Source gene: DAB1

Class: DEG_SCF_FBW7_1

Location: 500:507

E3 ligase: FBXW7

DEGRON score: 0.9028

ASA_SCORE: 88.0125

COIL: 0.8955

CONS_SCORE: 0.5005

DSS_SCORE: 0.5603

HELIX: 0.0758

FCONS_SCORE: 0.9581

RIG_SCORE: 0.7083

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D507Y	TCGA-29-1770	OV	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.7325
p.A500T	TCGA-DF-A2KU	UCEC	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.7139
p.D502N	TCGA-DA-A95Z	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.6932
p.D507N	TCGA-FS-A1ZZ	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.6932
p.P503S	TCGA-BF-AAP2	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.6752
p.S498F	TCGA-AP-A1DV	UCEC	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.2778
p.S498F	SK-MEL-2	skin	COSMIC	LNLTPVTS	DEG_SCF_FBW7_1	0.2778
p.E511D	TCGA-AA-3663	COAD	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.2222
p.S495L	TCGA-GF-A6C9	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1944
p.S513R	SNU-81	large_intestine	COSMIC	LNLTPVTS	DEG_SCF_FBW7_1	0.1667
p.S493F	TCGA-3N-A9WC	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.S493F	TCGA-DA-A1I1	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.S493F	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.S493F	ACH-000825	Lung Cancer	CCLE	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.S493F	HOP-92	lung	COSMIC	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.E514Q	TCGA-AG-4008	READ	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.E514G	TCGA-SI-A71O	SARC	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1389
p.P492A	TCGA-55-7907	LUAD	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.1111
p.S515C	SIDM02070	Esophageal Carcinoma	GDSC	LNLTPVTS	DEG_SCF_FBW7_1	0.1111
p.S515R	SIDM00193	Colorectal Carcinoma	GDSC	LNLTPVTS	DEG_SCF_FBW7_1	0.1111
p.S515R	ACH-000991	Colon/Colorectal Cancer	CCLE	LNLTPVTS	DEG_SCF_FBW7_1	0.1111
p.S515R	SNU-81	large_intestine	COSMIC	LNLTPVTS	DEG_SCF_FBW7_1	0.1111
p.P516L	TCGA-W3-AA1V	SKCM	TCGA	LNLTPVTS	DEG_SCF_FBW7_1	0.0833
p.S491F	HOP-92	lung	COSMIC	LNLTPVTS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75553	Disabled homolog 1	DEG_SCF_FBW7_1	500:507	LNLTPVTS	FBXW7	0.9028	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons