DegronMD

Uniprot ID: Q8N0Z2

Source protein: Actin-binding Rho-activating protein

Source gene: ABRA

Class: LIG_APCC_ABBA_1

Location: 262:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9933

ASA_SCORE: 75.4167

COIL: 0.818

CONS_SCORE: 0.602

DSS_SCORE: 0.3993

HELIX: 0.1582

FCONS_SCORE: 1.2207

RIG_SCORE: 0.7426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S266T	TCGA-73-4666	LUAD	TCGA	LNPFSE	LIG_APCC_ABBA_1	0.6005
p.S266T	DO26230	LUAD	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.6005
p.W252C	TCGA-CK-4951	COAD	TCGA	LNPFSE	LIG_APCC_ABBA_1	0.0556
p.W252C	DO10582	COAD	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.0556
p.P264H	TCGA-EE-A2GT	SKCM	TCGA	LNPFSE	LIG_APCC_ABBA_1	0.7694
p.P264H	TCGA-ER-A42K	SKCM	TCGA	LNPFSE	LIG_APCC_ABBA_1	0.7694
p.P264H	DO37946	SKCM	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.7694
p.P264H	DO51252	SKCM	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.7694
p.N263S	DO229473	LAML	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.5958
p.N263S	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.5958
p.N263S	SIDM00604	Oral Cavity Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.5958
p.N263S	SIDM00192	Colorectal Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.5958
p.A253D	DO228952	LICA	ICGC	LNPFSE	LIG_APCC_ABBA_1	0.0833
p.A274V	SIDM00683	Prostate Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.1389
p.A274V	ACH-000977	lymph_node	CCLE	LNPFSE	LIG_APCC_ABBA_1	0.1389
p.L273M	SIDM00697	Small Cell Lung Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.1667
p.L273M	ACH-000830	Lung Cancer	CCLE	LNPFSE	LIG_APCC_ABBA_1	0.1667
p.L273M	NCI-H1436	lung	COSMIC	LNPFSE	LIG_APCC_ABBA_1	0.1667
p.D270H	SIDM00932	Kidney Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	0.25
p.D270H	ACH-000457	Kidney Cancer	CCLE	LNPFSE	LIG_APCC_ABBA_1	0.25
p.D270H	CAL-54	kidney	COSMIC	LNPFSE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0Z2	Actin-binding Rho-activating protein	LIG_APCC_ABBA_1	262:267	LNPFSE	APC,CDC20,FZR1	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons