DegronMD - Q8N0Z2(ABRA)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P63T	TCGA-23-1022	OV	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2778
p.P63T	DO31070	OV	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2778
p.P69S	TCGA-2L-AAQE	PAAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.5641
p.P69S	DO51675	PAAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.5641
p.H72Q	TCGA-55-8089	LUAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.3056
p.H72Q	DO23690	LUAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.3056
p.S266T	TCGA-73-4666	LUAD	TCGA	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.6005
p.S266T	DO26230	LUAD	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.6005
p.H72N	TCGA-86-8585	LUAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.3056
p.H72N	DO24850	LUAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.3056
p.Q57H	TCGA-AX-A2HD	UCEC	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.Q57H	DO42608	UCEC	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.S77I	TCGA-B6-A0IE	BRCA	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1667
p.S77I	TCGA-CV-7432	HNSC	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1667
p.S77I	DO3055	BRCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1667
p.S77I	DO14159	HNSC	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1667
p.W252C	TCGA-CK-4951	COAD	TCGA	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.W252C	DO10582	COAD	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.G55E	TCGA-EE-A17X	SKCM	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0556
p.G55E	DO37931	SKCM	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0556
p.S81L	TCGA-EE-A20H	SKCM	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0556
p.S81L	DO37986	SKCM	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0556
p.P264H	TCGA-EE-A2GT	SKCM	TCGA	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7694
p.P264H	TCGA-ER-A42K	SKCM	TCGA	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7694
p.P264H	DO37946	SKCM	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7694
p.P264H	DO51252	SKCM	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7694
p.T56N	TCGA-QA-A7B7	LIHC	TCGA	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0833
p.T56N	DO52308	LIHC	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.0833
p.A62D	DO50326	ESAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.25
p.N263S	DO229473	LAML	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.5958
p.N263S	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.5958
p.N263S	SIDM00604	Oral Cavity Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.5958
p.N263S	SIDM00192	Colorectal Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.5958
p.A253D	DO228952	LICA	ICGC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0833
p.P68H	DO229041	LICA	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation altering degron motif	0.7694
p.A75G	DO222550	MELA	ICGC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2222
p.A274V	SIDM00683	Prostate Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1389
p.A274V	ACH-000977	lymph node	CCLE	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1389
p.L273M	SIDM00697	Small Cell Lung Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1667
p.L273M	ACH-000830	Lung Cancer	CCLE	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1667
p.L273M	NCI-H1436	lung	COSMIC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1667
p.D270H	SIDM00932	Kidney Carcinoma	GDSC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.25
p.D270H	ACH-000457	Kidney Cancer	CCLE	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.25
p.D270H	CAL-54	kidney	COSMIC	LNPFSE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.25
p.Q57K	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.Q57K	ACH-000747	Lung Cancer	CCLE	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.Q57K	NCI-H1703	lung	COSMIC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.1111
p.A75S	SIDM00667	Other Sarcomas	GDSC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2222
p.A75S	ACH-002246	Sarcoma	CCLE	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2222
p.A75S	Hs633T	soft tissue	COSMIC	PITPPTS	DEG_SCF_FBW7_1	65:71	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABRA

UniProt ID: Q8N0Z2

Entrez ID: 137735

Protein name: Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ABRA in