DegronMD

Uniprot ID: Q8N0Z2

Source protein: Actin-binding Rho-activating protein

Source gene: ABRA

Class: DEG_SCF_FBW7_1

Location: 65:71

E3 ligase: FBXW7

DEGRON score: 0.9344

ASA_SCORE: 81.4429

COIL: 0.921

CONS_SCORE: 0.3405

DSS_SCORE: 0.9095

HELIX: 0.0466

FCONS_SCORE: 0.9196

RIG_SCORE: 0.5522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P63T	TCGA-23-1022	OV	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.2778
p.P63T	DO31070	OV	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.2778
p.P69S	TCGA-2L-AAQE	PAAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.5641
p.P69S	DO51675	PAAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.5641
p.H72Q	TCGA-55-8089	LUAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.3056
p.H72Q	DO23690	LUAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.3056
p.H72N	TCGA-86-8585	LUAD	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.3056
p.H72N	DO24850	LUAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.3056
p.Q57H	TCGA-AX-A2HD	UCEC	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.1111
p.Q57H	DO42608	UCEC	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.1111
p.S77I	TCGA-B6-A0IE	BRCA	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.1667
p.S77I	TCGA-CV-7432	HNSC	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.1667
p.S77I	DO3055	BRCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.1667
p.S77I	DO14159	HNSC	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.1667
p.G55E	TCGA-EE-A17X	SKCM	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.0556
p.G55E	DO37931	SKCM	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.0556
p.S81L	TCGA-EE-A20H	SKCM	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.0556
p.S81L	DO37986	SKCM	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.0556
p.T56N	TCGA-QA-A7B7	LIHC	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.0833
p.T56N	DO52308	LIHC	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.0833
p.A62D	DO50326	ESAD	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.25
p.P68H	DO229041	LICA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7694
p.A75G	DO222550	MELA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.2222
p.Q57K	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PITPPTS	DEG_SCF_FBW7_1	0.1111
p.Q57K	ACH-000747	Lung Cancer	CCLE	PITPPTS	DEG_SCF_FBW7_1	0.1111
p.Q57K	NCI-H1703	lung	COSMIC	PITPPTS	DEG_SCF_FBW7_1	0.1111
p.A75S	SIDM00667	Other Sarcomas	GDSC	PITPPTS	DEG_SCF_FBW7_1	0.2222
p.A75S	ACH-002246	Sarcoma	CCLE	PITPPTS	DEG_SCF_FBW7_1	0.2222
p.A75S	Hs633T	soft_tissue	COSMIC	PITPPTS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1546:1552	PITPPTS	FBXW7	0.8312	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1625:1631	PITPPTS	FBXW7	0.9868	More...
Q8N0Z2	Actin-binding Rho-activating protein	DEG_SCF_FBW7_1	65:71	PITPPTS	FBXW7	0.9344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITPPTS

Degron related mutations and impact score

Drug responses associated with ABRA mutations

All proteins holding degron of PITPPTS