DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PITPPTS
Uniprot ID:
Q02817
Source protein:
Mucin-2
Source gene:
MUC2
Class:
DEG_SCF_FBW7_1
Location:
1546:1552
E3 ligase:
FBXW7
DEGRON score:
0.8312
ASA_SCORE:
95.7857
COIL:
0.9467
CONS_SCORE:
0.248
DSS_SCORE:
0.8248
HELIX:
0.0111
FCONS_SCORE:
0.9378
RIG_SCORE:
0.5862
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1550N
DO51005
LAML
ICGC
PITPPTS
DEG_SCF_FBW7_1
0.7055
p.T1555I
DO222510
MELA
ICGC
PITPPTS
DEG_SCF_FBW7_1
0.25
p.P1540S
DO229208
THCA
ICGC
PITPPTS
DEG_SCF_FBW7_1
0.1667
p.P1540S
DO229245
THCA
ICGC
PITPPTS
DEG_SCF_FBW7_1
0.1667
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Drug responses associated with MUC2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PITPPTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N0Z2
Actin-binding Rho-activating protein
DEG_SCF_FBW7_1
65:71
PITPPTS
FBXW7
0.9344
More...
Q02817
Mucin-2
DEG_SCF_FBW7_1
1546:1552
PITPPTS
FBXW7
0.8312
More...
Q02817
Mucin-2
DEG_SCF_FBW7_1
1625:1631
PITPPTS
FBXW7
0.9868
More...
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