DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1546:1552

E3 ligase: FBXW7

DEGRON score: 0.8312

ASA_SCORE: 95.7857

COIL: 0.9467

CONS_SCORE: 0.248

DSS_SCORE: 0.8248

HELIX: 0.0111

FCONS_SCORE: 0.9378

RIG_SCORE: 0.5862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1550N	DO51005	LAML	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7055
p.T1555I	DO222510	MELA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.25
p.P1540S	DO229208	THCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.1667
p.P1540S	DO229245	THCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1546:1552	PITPPTS	FBXW7	0.8312	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1625:1631	PITPPTS	FBXW7	0.9868	More...
Q8N0Z2	Actin-binding Rho-activating protein	DEG_SCF_FBW7_1	65:71	PITPPTS	FBXW7	0.9344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons