DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1625:1631

E3 ligase: FBXW7

DEGRON score: 0.9868

ASA_SCORE: 96.2286

COIL: 0.959

CONS_SCORE: 0.3301

DSS_SCORE: 0.8212

HELIX: 0.0113

FCONS_SCORE: 1.1321

RIG_SCORE: 0.5862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1628N	TCGA-KM-8440	KICH	TCGA	PITPPTS	DEG_SCF_FBW7_1	0.7055
p.T1628N	DO220357	KICH	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7055
p.P1634A	DO3293	BRCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.25
p.T1630A	DO218242	GACA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.6028
p.T1630A	DO229253	THCA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.6028
p.A1631P	DO51019	LAML	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7503
p.A1631P	DO228911	LICA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7503
p.A1631P	DO228921	LICA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7503
p.A1631P	DO229035	LICA	ICGC	PITPPTS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1546:1552	PITPPTS	FBXW7	0.8312	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1625:1631	PITPPTS	FBXW7	0.9868	More...
Q8N0Z2	Actin-binding Rho-activating protein	DEG_SCF_FBW7_1	65:71	PITPPTS	FBXW7	0.9344	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons