DegronMD

Uniprot ID: Q9HCE5

Source protein: N6-adenosine-methyltransferase non-catalytic subunit

Source gene: METTL14

Class: LIG_APCC_ABBA_1

Location: 113:118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9724

ASA_SCORE: 59.0833

COIL: 0.7922

CONS_SCORE: 0.61

DSS_SCORE: 0.3848

HELIX: 0.124

FCONS_SCORE: 1.0615

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D125E	TCGA-CU-A3YL	BLCA	TCGA	LNPHND	LIG_APCC_ABBA_1	0.1389
p.D125E	DO834	BLCA	ICGC	LNPHND	LIG_APCC_ABBA_1	0.1389
p.Y119C	DO49478	PACA	ICGC	LNPHND	LIG_APCC_ABBA_1	0.3056
p.P115L	SIDM00221	Melanoma	GDSC	LNPHND	LIG_APCC_ABBA_1	0.6471
p.P115L	ACH-002388	Skin Cancer	CCLE	LNPHND	LIG_APCC_ABBA_1	0.6471
p.T126S	SIDM00892	Breast Carcinoma	GDSC	LNPHND	LIG_APCC_ABBA_1	0.1111
p.T126S	ACH-000818	Breast Cancer	CCLE	LNPHND	LIG_APCC_ABBA_1	0.1111
p.T126S	BT-483	breast	COSMIC	LNPHND	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE5	N6-adenosine-methyltransferase non-catalytic subunit	LIG_APCC_ABBA_1	113:118	LNPHND	APC,CDC20,FZR1	0.9724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons