DegronMD

Uniprot ID: A1KZ92

Source protein: Probable oxidoreductase PXDNL

Source gene: PXDNL

Class: LIG_APCC_ABBA_1

Location: 988:993

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7285

ASA_SCORE: 78.5833

COIL: 0.8702

CONS_SCORE: 0.5177

DSS_SCORE: 0.2938

HELIX: 0.1267

FCONS_SCORE: 0.8444

RIG_SCORE: 0.7479

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H991N	TCGA-05-4382	LUAD	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.7423
p.H991N	DO24900	LUAD	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.7423
p.V997F	TCGA-22-5472	LUSC	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.2222
p.V997F	DO27421	LUSC	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.2222
p.R1002W	TCGA-CV-A45Z	HNSC	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.0833
p.R1002W	DO52064	HNSC	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.0833
p.T983M	TCGA-D1-A0ZR	UCEC	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.1944
p.T983M	DO40822	UCEC	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1944
p.G994E	TCGA-D3-A2JO	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	TCGA-D3-A3MV	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	TCGA-EE-A2MS	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	TCGA-EE-A3J5	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	TCGA-ER-A19K	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	TCGA-GN-A262	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO37515	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO37567	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO37727	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO47331	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO47672	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	DO47619	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994E	ACH-001982	Metastasis	CCLE	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	TCGA-DM-A0XD	COAD	TCGA	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	DO10228	COAD	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	DO35148	PACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	DO35315	PACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	DO47052	RECA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987T	SIDM02029	Colorectal Carcinoma	GDSC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987S	DO224852	BRCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.A987S	DO52550	BRCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.M981V	DO229010	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1389
p.M981V	DO229013	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1389
p.M981V	DO229016	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1389
p.M981V	DO229003	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1389
p.M981V	DO229005	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.1389
p.E993D	DO233109	GACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.5647
p.H978L	DO228278	LICA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.0556
p.E984K	DO222542	MELA	ICGC	LNPHWE	LIG_APCC_ABBA_1	0.2222
p.G994R	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.G994R	ACH-000813	Lung Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	0.3056
p.P990L	ACH-000123	Ovarian Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	0.6471
p.Q999K	ACH-000248	Breast Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	0.1667
p.R1002M	ACH-002027	Endometrial/Uterine Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNPHWE

Degron related mutations and impact score

Drug responses associated with PXDNL mutations

All proteins holding degron of LNPHWE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1KZ92	Probable oxidoreductase PXDNL	LIG_APCC_ABBA_1	988:993	LNPHWE	APC,CDC20,FZR1	0.7285	More...