DegronMD - A1KZ92(PXDNL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H991N	TCGA-05-4382	LUAD	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation altering degron motif	0.7423
p.H991N	DO24900	LUAD	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation altering degron motif	0.7423
p.R281Q	TCGA-06-5416	GBM	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.3056
p.R281Q	DO10880	GBM	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.3056
p.R281Q	DO222837	MELA	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.3056
p.R281Q	SIDM00118	Colorectal Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.3056
p.R281Q	HCC2998	large intestine	COSMIC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.3056
p.V997F	TCGA-22-5472	LUSC	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.2222
p.V997F	DO27421	LUSC	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.2222
p.E297D	TCGA-55-6985	LUAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0556
p.E297D	DO25659	LUAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0556
p.V284A	TCGA-AP-A056	UCEC	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6936
p.V284A	DO43971	UCEC	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6936
p.R296G	TCGA-B0-5713	KIRC	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.R296G	DO17216	KIRC	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273A	TCGA-BR-8080	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273A	DO38651	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.R293Q	TCGA-BS-A0UF	UCEC	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.R293Q	TCGA-EE-A29H	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.R293Q	TCGA-EE-A2MS	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.R293Q	DO37535	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.R293Q	DO37567	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.R293Q	DO41488	UCEC	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.V284E	TCGA-CN-A63W	HNSC	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7693
p.V284E	DO49031	HNSC	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.7693
p.D287N	TCGA-CQ-A4CD	HNSC	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6932
p.D287N	DO234467	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6932
p.D287N	DO49038	HNSC	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6932
p.D287N	DO50657	ORCA	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation altering degron motif	0.6932
p.R1002W	TCGA-CV-A45Z	HNSC	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.0833
p.R1002W	DO52064	HNSC	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.0833
p.T983M	TCGA-D1-A0ZR	UCEC	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1944
p.T983M	DO40822	UCEC	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1944
p.G994E	TCGA-D3-A2JO	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	TCGA-D3-A3MV	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	TCGA-EE-A2MS	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	TCGA-EE-A3J5	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	TCGA-ER-A19K	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	TCGA-GN-A262	SKCM	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO37515	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO37567	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO37727	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO47331	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO47672	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	DO47619	SKCM	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994E	ACH-001982	Metastasis	CCLE	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.L276V	TCGA-D7-5578	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.L276V	DO38475	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1667
p.A987T	TCGA-DM-A0XD	COAD	TCGA	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987T	DO10228	COAD	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987T	DO35148	PACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987T	DO35315	PACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987T	DO47052	RECA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987T	SIDM02029	Colorectal Carcinoma	GDSC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.S273P	TCGA-HU-A4GC	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	DO50408	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	DO233206	GACA	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	DO47797	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	SIDM00217	Colorectal Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	ACH-000999	Colon/Colorectal Cancer	CCLE	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273P	SNU-1040	large intestine	COSMIC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.M291I	TCGA-RP-A694	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.M291I	DO51269	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.A987S	DO224852	BRCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.A987S	DO52550	BRCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.M981V	DO229010	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1389
p.M981V	DO229013	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1389
p.M981V	DO229016	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1389
p.M981V	DO229003	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1389
p.M981V	DO229005	COCA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1389
p.L290P	DO234152	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.25
p.E993D	DO233109	GACA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation altering degron motif	0.5647
p.H978L	DO228278	LICA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.0556
p.N294K	DO25104	LUAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.1389
p.H272Q	DO222399	MELA	ICGC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0556
p.E984K	DO222542	MELA	ICGC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.2222
p.S273L	SIDM00683	Prostate Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273L	ACH-000977	lymph node	CCLE	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.S273L	LNCaP-Clone-FGC	prostate	COSMIC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.0833
p.D278N	SIDM00998	Glioblastoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.D278N	ACH-000137	Brain Cancer	CCLE	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.D278N	8-MG-BA	central nervous system	COSMIC	LNVFDD	LIG_APCC_ABBA_1	282:287	Mutation rewiring degron network	0.2222
p.G994R	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.G994R	ACH-000813	Lung Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.3056
p.P990L	ACH-000123	Ovarian Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation altering degron motif	0.6471
p.Q999K	ACH-000248	Breast Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.1667
p.R1002M	ACH-002027	Endometrial/Uterine Cancer	CCLE	LNPHWE	LIG_APCC_ABBA_1	988:993	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PXDNL

UniProt ID: A1KZ92

Entrez ID: 137902

Protein name: Probable oxidoreductase PXDNL (EC 1.-.-.-) (Cardiac peroxidase) (Inactive peroxidasin-like protein) (Polysomal ribonuclease 1) (PRM1) (Vascular peroxidase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PXDNL in