DegronMD

Uniprot ID: A1KZ92

Source protein: Probable oxidoreductase PXDNL

Source gene: PXDNL

Class: LIG_APCC_ABBA_1

Location: 282:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5735

ASA_SCORE: 50.5167

COIL: 0.4353

CONS_SCORE: 0.355

DSS_SCORE: 0.2784

HELIX: 0.0157

FCONS_SCORE: 0.9961

RIG_SCORE: 0.84

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R281Q	TCGA-06-5416	GBM	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.3056
p.R281Q	DO10880	GBM	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.3056
p.R281Q	DO222837	MELA	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.3056
p.R281Q	SIDM00118	Colorectal Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	0.3056
p.R281Q	HCC2998	large_intestine	COSMIC	LNVFDD	LIG_APCC_ABBA_1	0.3056
p.E297D	TCGA-55-6985	LUAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.0556
p.E297D	DO25659	LUAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0556
p.V284A	TCGA-AP-A056	UCEC	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.6936
p.V284A	DO43971	UCEC	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.6936
p.R296G	TCGA-B0-5713	KIRC	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.R296G	DO17216	KIRC	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273A	TCGA-BR-8080	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273A	DO38651	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.R293Q	TCGA-BS-A0UF	UCEC	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.R293Q	TCGA-EE-A29H	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.R293Q	TCGA-EE-A2MS	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.R293Q	DO37535	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.R293Q	DO37567	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.R293Q	DO41488	UCEC	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.V284E	TCGA-CN-A63W	HNSC	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.7693
p.V284E	DO49031	HNSC	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.7693
p.D287N	TCGA-CQ-A4CD	HNSC	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.6932
p.D287N	DO234467	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.6932
p.D287N	DO49038	HNSC	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.6932
p.D287N	DO50657	ORCA	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.6932
p.L276V	TCGA-D7-5578	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.L276V	DO38475	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.1667
p.S273P	TCGA-HU-A4GC	STAD	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	DO50408	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	DO233206	GACA	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	DO47797	STAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	SIDM00217	Colorectal Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	ACH-000999	Colon/Colorectal Cancer	CCLE	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273P	SNU-1040	large_intestine	COSMIC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.M291I	TCGA-RP-A694	SKCM	TCGA	LNVFDD	LIG_APCC_ABBA_1	0.2222
p.M291I	DO51269	SKCM	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.2222
p.L290P	DO234152	ESAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.25
p.N294K	DO25104	LUAD	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.1389
p.H272Q	DO222399	MELA	ICGC	LNVFDD	LIG_APCC_ABBA_1	0.0556
p.S273L	SIDM00683	Prostate Carcinoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273L	ACH-000977	lymph_node	CCLE	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.S273L	LNCaP-Clone-FGC	prostate	COSMIC	LNVFDD	LIG_APCC_ABBA_1	0.0833
p.D278N	SIDM00998	Glioblastoma	GDSC	LNVFDD	LIG_APCC_ABBA_1	0.2222
p.D278N	ACH-000137	Brain Cancer	CCLE	LNVFDD	LIG_APCC_ABBA_1	0.2222
p.D278N	8-MG-BA	central_nervous_system	COSMIC	LNVFDD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNVFDD

Degron related mutations and impact score

Drug responses associated with PXDNL mutations

All proteins holding degron of LNVFDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1KZ92	Probable oxidoreductase PXDNL	LIG_APCC_ABBA_1	282:287	LNVFDD	APC,CDC20,FZR1	0.5735	More...