DegronMD

Uniprot ID: Q8WXE9

Source protein: Stonin-2

Source gene: STON2

Class: DEG_SCF_FBW7_1

Location: 297:304

E3 ligase: FBXW7

DEGRON score: 0.994

ASA_SCORE: 87.0125

COIL: 0.8761

CONS_SCORE: 0.4224

DSS_SCORE: 0.4683

HELIX: 0.0916

FCONS_SCORE: 1.1429

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R299H	TCGA-AN-A0AK	BRCA	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.7133
p.R299H	DO1608	BRCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.7133
p.T300M	TCGA-B5-A11H	UCEC	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.8534
p.T300M	TCGA-DD-A1EH	LIHC	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.8534
p.T300M	DO22986	LIHC	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.8534
p.T300M	DO42825	UCEC	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.8534
p.N313S	TCGA-BF-AAP7	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.0833
p.N313S	DO219472	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.0833
p.S296F	TCGA-DK-A3IU	BLCA	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.75
p.S296F	DO612	BLCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.75
p.S295F	TCGA-EB-A85J	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.2778
p.S295F	DO50297	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.2778
p.T312A	TCGA-EE-A29S	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	0.1111
p.T312A	DO37936	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.1111
p.S307P	DO229010	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.S307P	DO229013	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.S307P	DO229016	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.S307P	DO229003	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.S307P	DO230659	LAML	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.S307P	DO231140	LAML	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.6944
p.T312N	DO228952	LICA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	0.1111
p.D293Y	SIDM00329	Hodgkin's Lymphoma	GDSC	LNRTPSVT	DEG_SCF_FBW7_1	0.2222
p.D293Y	ACH-000806	Lymphoma	CCLE	LNRTPSVT	DEG_SCF_FBW7_1	0.2222
p.D293Y	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	LNRTPSVT	DEG_SCF_FBW7_1	0.2222
p.R299C	SIDM00839	Colorectal Carcinoma	GDSC	LNRTPSVT	DEG_SCF_FBW7_1	0.719
p.R299C	LoVo	large_intestine	COSMIC	LNRTPSVT	DEG_SCF_FBW7_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXE9	Stonin-2	DEG_SCF_FBW7_1	297:304	LNRTPSVT	FBXW7	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNRTPSVT

Degron related mutations and impact score

Drug responses associated with STON2 mutations

All proteins holding degron of LNRTPSVT