DegronMD - Q8WXE9(STON2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S373N	TCGA-55-A4DG	LUAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.S373N	DO26337	LUAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.S373I	TCGA-97-A4LX	LUAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.S373I	DO218934	LUAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.F369C	TCGA-AA-3984	COAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.F369C	DO9002	COAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.N268S	TCGA-AG-A002	READ	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.2222
p.A366V	TCGA-AJ-A3OJ	UCEC	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.A366V	DO42753	UCEC	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.R299H	TCGA-AN-A0AK	BRCA	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7133
p.R299H	DO1608	BRCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7133
p.T300M	TCGA-B5-A11H	UCEC	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.8534
p.T300M	TCGA-DD-A1EH	LIHC	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.8534
p.T300M	DO22986	LIHC	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.8534
p.T300M	DO42825	UCEC	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.8534
p.N313S	TCGA-BF-AAP7	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.N313S	DO219472	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.M270I	TCGA-DA-A1I7	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1667
p.M270I	DO37951	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1667
p.P246S	TCGA-DI-A1BU	UCEC	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.0556
p.P246S	DO42023	UCEC	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.0556
p.S296F	TCGA-DK-A3IU	BLCA	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.75
p.S296F	DO612	BLCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.75
p.S295F	TCGA-EB-A85J	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2778
p.S295F	DO50297	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2778
p.T312A	TCGA-EE-A29S	SKCM	TCGA	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1111
p.T312A	DO37936	SKCM	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1111
p.S269L	TCGA-EE-A2MF	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1944
p.S269L	DO222491	MELA	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1944
p.S269L	DO51249	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1944
p.N268I	TCGA-EE-A2MJ	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.2222
p.N268I	DO38099	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.2222
p.T248A	TCGA-FI-A2D0	UCEC	TCGA	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1111
p.T248A	DO43891	UCEC	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1111
p.S307P	DO229010	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.S307P	DO229013	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.S307P	DO229016	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.S307P	DO229003	COCA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.S307P	DO230659	LAML	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.S307P	DO231140	LAML	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation blocking phosphorylation signal	0.6944
p.T312N	DO228952	LICA	ICGC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1111
p.P246Q	DO229045	LICA	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.0556
p.N268D	DO50851	LIRI	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.2222
p.P266L	DO220902	MELA	ICGC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.2778
p.K353N	DO33136	PACA	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation blocking ubiquitination signal	0.7222
p.S346F	SIDM00392	Melanoma	GDSC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.S346F	ACH-000810	Skin Cancer	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.S346F	SK-MEL-30	skin	COSMIC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.P250S	SIDM01175	Other Sarcomas	GDSC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1667
p.P250S	ACH-002309	Sarcoma	CCLE	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1667
p.P250S	SW684	soft tissue	COSMIC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation rewiring degron network	0.1667
p.D293Y	SIDM00329	Hodgkin's Lymphoma	GDSC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.D293Y	ACH-000806	Lymphoma	CCLE	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.D293Y	L-540	haematopoietic and lymphoid tissue	COSMIC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.P263S	SIDM00516	Melanoma	GDSC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation altering degron motif	0.6752
p.P263S	MZ7-mel	skin	COSMIC	PPSASVIPD	DEG_SIAH_1	256:264	Mutation altering degron motif	0.6752
p.R299C	SIDM00839	Colorectal Carcinoma	GDSC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.719
p.R299C	LoVo	large intestine	COSMIC	LNRTPSVT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.719
p.D371N	SIDM01750	Melanoma	GDSC	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.D371N	ACH-000801	Skin Cancer	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.S358F	ACH-001616	Lymphoma	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STON2

UniProt ID: Q8WXE9

Entrez ID: 85439

Protein name: Stonin-2 (Stoned B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STON2 in