DegronMD

Uniprot ID: Q8WXE9

Source protein: Stonin-2

Source gene: STON2

Class: DEG_SIAH_1

Location: 256:264

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9937

ASA_SCORE: 77.1

COIL: 0.9172

CONS_SCORE: 0.3626

DSS_SCORE: 0.5141

HELIX: 0.0271

FCONS_SCORE: 0.9252

RIG_SCORE: 0.6657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N268S	TCGA-AG-A002	READ	TCGA	PPSASVIPD	DEG_SIAH_1	0.2222
p.M270I	TCGA-DA-A1I7	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	0.1667
p.M270I	DO37951	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	0.1667
p.P246S	TCGA-DI-A1BU	UCEC	TCGA	PPSASVIPD	DEG_SIAH_1	0.0556
p.P246S	DO42023	UCEC	ICGC	PPSASVIPD	DEG_SIAH_1	0.0556
p.S269L	TCGA-EE-A2MF	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	0.1944
p.S269L	DO222491	MELA	ICGC	PPSASVIPD	DEG_SIAH_1	0.1944
p.S269L	DO51249	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	0.1944
p.N268I	TCGA-EE-A2MJ	SKCM	TCGA	PPSASVIPD	DEG_SIAH_1	0.2222
p.N268I	DO38099	SKCM	ICGC	PPSASVIPD	DEG_SIAH_1	0.2222
p.T248A	TCGA-FI-A2D0	UCEC	TCGA	PPSASVIPD	DEG_SIAH_1	0.1111
p.T248A	DO43891	UCEC	ICGC	PPSASVIPD	DEG_SIAH_1	0.1111
p.P246Q	DO229045	LICA	ICGC	PPSASVIPD	DEG_SIAH_1	0.0556
p.N268D	DO50851	LIRI	ICGC	PPSASVIPD	DEG_SIAH_1	0.2222
p.P266L	DO220902	MELA	ICGC	PPSASVIPD	DEG_SIAH_1	0.2778
p.P250S	SIDM01175	Other Sarcomas	GDSC	PPSASVIPD	DEG_SIAH_1	0.1667
p.P250S	ACH-002309	Sarcoma	CCLE	PPSASVIPD	DEG_SIAH_1	0.1667
p.P250S	SW684	soft_tissue	COSMIC	PPSASVIPD	DEG_SIAH_1	0.1667
p.P263S	SIDM00516	Melanoma	GDSC	PPSASVIPD	DEG_SIAH_1	0.6752
p.P263S	MZ7-mel	skin	COSMIC	PPSASVIPD	DEG_SIAH_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXE9	Stonin-2	DEG_SIAH_1	256:264	PPSASVIPD	SIAH1,SIAH2,SIAH3	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons