DegronMD

Uniprot ID: Q8WXE9

Source protein: Stonin-2

Source gene: STON2

Class: DEG_APCC_DBOX_1

Location: 355:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8396

ASA_SCORE: 73.4778

COIL: 0.559

CONS_SCORE: 0.3738

DSS_SCORE: 0.3861

HELIX: 0.1664

FCONS_SCORE: 1.1016

RIG_SCORE: 0.8058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S373N	TCGA-55-A4DG	LUAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	0.0556
p.S373N	DO26337	LUAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	0.0556
p.S373I	TCGA-97-A4LX	LUAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	0.0556
p.S373I	DO218934	LUAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	0.0556
p.F369C	TCGA-AA-3984	COAD	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	0.1667
p.F369C	DO9002	COAD	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	0.1667
p.A366V	TCGA-AJ-A3OJ	UCEC	TCGA	QRDSLIVIY	DEG_APCC_DBOX_1	0.25
p.A366V	DO42753	UCEC	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	0.25
p.K353N	DO33136	PACA	ICGC	QRDSLIVIY	DEG_APCC_DBOX_1	0.7222
p.S346F	SIDM00392	Melanoma	GDSC	QRDSLIVIY	DEG_APCC_DBOX_1	0.0833
p.S346F	ACH-000810	Skin Cancer	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	0.0833
p.S346F	SK-MEL-30	skin	COSMIC	QRDSLIVIY	DEG_APCC_DBOX_1	0.0833
p.D371N	SIDM01750	Melanoma	GDSC	QRDSLIVIY	DEG_APCC_DBOX_1	0.1111
p.D371N	ACH-000801	Skin Cancer	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	0.1111
p.S358F	ACH-001616	Lymphoma	CCLE	QRDSLIVIY	DEG_APCC_DBOX_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXE9	Stonin-2	DEG_APCC_DBOX_1	355:363	QRDSLIVIY	APC,CDC20,FZR1	0.8396	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons