DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3971:3977

E3 ligase: FBXW7

DEGRON score: 0.9147

ASA_SCORE: 96.7714

COIL: 0.9459

CONS_SCORE: 0.6618

DSS_SCORE: 0.5201

HELIX: 0.0111

FCONS_SCORE: 1.0076

RIG_SCORE: 0.6591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3984Y	TCGA-23-1110	OV	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.1389
p.S3984Y	DO29398	OV	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.1389
p.T3981A	TCGA-BH-A1FC	BRCA	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.2222
p.T3981A	DO5661	BRCA	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.2222
p.T3973A	TCGA-BR-8680	STAD	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.7139
p.T3973A	DO47769	STAD	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.7139
p.N3972S	TCGA-D3-A8GI	SKCM	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.5958
p.N3972S	DO50284	SKCM	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.5958
p.S3986L	TCGA-D8-A1JA	BRCA	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.0833
p.S3986L	TCGA-WE-A8K1	SKCM	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.0833
p.S3986L	DO2819	BRCA	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.0833
p.S3986L	DO220891	MELA	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.0833
p.S3986L	DO51280	SKCM	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.0833
p.P3974S	TCGA-DF-A2KN	UCEC	TCGA	LNTPSTS	DEG_SCF_FBW7_1	0.6752
p.P3974S	DO218840	SKCA	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.6752
p.P3974S	DO223282	UCEC	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.6752
p.E3970K	DO222494	MELA	ICGC	LNTPSTS	DEG_SCF_FBW7_1	0.3056
p.T3973P	SIDM00721	Small Cell Lung Carcinoma	GDSC	LNTPSTS	DEG_SCF_FBW7_1	0.7031
p.T3973P	ACH-002171	Lung Cancer	CCLE	LNTPSTS	DEG_SCF_FBW7_1	0.7031
p.T3973P	NCI-H250	lung	COSMIC	LNTPSTS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3971:3977	LNTPSTS	FBXW7	0.9147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons