DegronMD

Uniprot ID: Q96QC0

Source protein: Serine/threonine-protein phosphatase 1 regulatory subunit 10

Source gene: PPP1R10

Class: DEG_SCF_FBW7_1

Location: 266:273

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 88.55

COIL: 0.863

CONS_SCORE: 0.4992

DSS_SCORE: 0.5107

HELIX: 0.1114

FCONS_SCORE: 1.0318

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P257S	TCGA-04-1356	OV	TCGA	LNTTPNAT	DEG_SCF_FBW7_1	0.0833
p.P257S	DO222702	MELA	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	0.0833
p.P257S	DO29568	OV	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	0.0833
p.K277Q	TCGA-AZ-4681	COAD	TCGA	LNTTPNAT	DEG_SCF_FBW7_1	0.3333
p.K277Q	DO9306	COAD	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	0.3333
p.I280M	DO223024	ESCA	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	0.1389
p.P258L	SIDM00971	Breast Carcinoma	GDSC	LNTTPNAT	DEG_SCF_FBW7_1	0.1111
p.P258L	ACH-000828	Breast Cancer	CCLE	LNTTPNAT	DEG_SCF_FBW7_1	0.1111
p.P258L	ZR-75-30	breast	COSMIC	LNTTPNAT	DEG_SCF_FBW7_1	0.1111
p.T256A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LNTTPNAT	DEG_SCF_FBW7_1	0.5
p.T256A	ACH-000964	Leukemia	CCLE	LNTTPNAT	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QC0	Serine/threonine-protein phosphatase 1 regulatory subunit 10	DEG_SCF_FBW7_1	266:273	LNTTPNAT	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons