DegronMD - Q96QC0(PPP1R10)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P257S	TCGA-04-1356	OV	TCGA	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.0833
p.P257S	DO222702	MELA	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.0833
p.P257S	DO29568	OV	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.0833
p.E530K	TCGA-56-A5DS	LUSC	TCGA	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation altering degron motif	0.591
p.E530K	DO45494	LUSC	ICGC	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation altering degron motif	0.591
p.K277Q	TCGA-AZ-4681	COAD	TCGA	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation substituting flanking lysine	0.3333
p.K277Q	DO9306	COAD	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation substituting flanking lysine	0.3333
p.G543S	TCGA-D9-A4Z3	SKCM	TCGA	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation rewiring degron network	0.1111
p.G543S	DO47555	SKCM	ICGC	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation rewiring degron network	0.1111
p.I280M	DO223024	ESCA	ICGC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1389
p.G544D	DO233259	GACA	ICGC	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation rewiring degron network	0.0833
p.P258L	SIDM00971	Breast Carcinoma	GDSC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.P258L	ACH-000828	Breast Cancer	CCLE	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.P258L	ZR-75-30	breast	COSMIC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation rewiring degron network	0.1111
p.E525D	SIDM00861	Ovarian Carcinoma	GDSC	MDETPYVE	DEG_SCF_FBW7_2	528:535	Mutation rewiring degron network	0.25
p.T256A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation blocking phosphorylation signal	0.5
p.T256A	ACH-000964	Leukemia	CCLE	LNTTPNAT	DEG_SCF_FBW7_1	266:273	Mutation blocking phosphorylation signal	0.5

Kaplan plot for PPP1R10 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R10

UniProt ID: Q96QC0

Entrez ID: 5514

Protein name: Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPP1R10 in