DegronMD

Uniprot ID: Q96QC0

Source protein: Serine/threonine-protein phosphatase 1 regulatory subunit 10

Source gene: PPP1R10

Class: DEG_SCF_FBW7_2

Location: 528:535

E3 ligase: FBXW7

DEGRON score: 0.6509

ASA_SCORE: 85.1375

COIL: 0.8358

CONS_SCORE: 0.2688

DSS_SCORE: 0.6789

HELIX: 0.1009

FCONS_SCORE: 0.5573

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E530K	TCGA-56-A5DS	LUSC	TCGA	MDETPYVE	DEG_SCF_FBW7_2	0.591
p.E530K	DO45494	LUSC	ICGC	MDETPYVE	DEG_SCF_FBW7_2	0.591
p.G543S	TCGA-D9-A4Z3	SKCM	TCGA	MDETPYVE	DEG_SCF_FBW7_2	0.1111
p.G543S	DO47555	SKCM	ICGC	MDETPYVE	DEG_SCF_FBW7_2	0.1111
p.G544D	DO233259	GACA	ICGC	MDETPYVE	DEG_SCF_FBW7_2	0.0833
p.E525D	SIDM00861	Ovarian Carcinoma	GDSC	MDETPYVE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QC0	Serine/threonine-protein phosphatase 1 regulatory subunit 10	DEG_SCF_FBW7_2	528:535	MDETPYVE	FBXW7	0.6509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons