DegronMD

Uniprot ID: Q96FJ0

Source protein: AMSH-like protease

Source gene: STAMBPL1

Class: LIG_APCC_ABBA_1

Location: 223:228

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6791

ASA_SCORE: 55.5333

COIL: 0.5282

CONS_SCORE: 0.4309

DSS_SCORE: 0.4917

HELIX: 0.3523

FCONS_SCORE: 1.1641

RIG_SCORE: 0.7761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N237D	TCGA-IB-7651	PAAD	TCGA	LNVFAD	LIG_APCC_ABBA_1	0.0833
p.N237D	DO46657	PAAD	ICGC	LNVFAD	LIG_APCC_ABBA_1	0.0833
p.V225A	TCGA-XK-AAIW	PRAD	TCGA	LNVFAD	LIG_APCC_ABBA_1	0.6936
p.V225A	DO51407	PRAD	ICGC	LNVFAD	LIG_APCC_ABBA_1	0.6936
p.N231Y	DO227686	COCA	ICGC	LNVFAD	LIG_APCC_ABBA_1	0.25
p.S233I	DO229009	LICA	ICGC	LNVFAD	LIG_APCC_ABBA_1	0.1944
p.L223P	SIDM00992	Thyroid Gland Carcinoma	GDSC	LNVFAD	LIG_APCC_ABBA_1	0.7582
p.L223P	ACH-000456	Thyroid Cancer	CCLE	LNVFAD	LIG_APCC_ABBA_1	0.7582
p.L223P	BCPAP	thyroid	COSMIC	LNVFAD	LIG_APCC_ABBA_1	0.7582
p.K232Q	SIDM00118	Colorectal Carcinoma	GDSC	LNVFAD	LIG_APCC_ABBA_1	0.3333
p.K232Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LNVFAD	LIG_APCC_ABBA_1	0.3333
p.K232Q	HCC2998	large_intestine	COSMIC	LNVFAD	LIG_APCC_ABBA_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FJ0	AMSH-like protease	LIG_APCC_ABBA_1	223:228	LNVFAD	APC,CDC20,FZR1	0.6791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons