DegronMD - Q96FJ0(STAMBPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V425L	TCGA-77-7465	LUSC	TCGA	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.V425L	DO27699	LUSC	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.V432L	TCGA-B8-4148	KIRC	TCGA	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.2778
p.V432L	DO19168	KIRC	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.2778
p.L424F	TCGA-BG-A220	UCEC	TCGA	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0556
p.L424F	DO41784	UCEC	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0556
p.L435M	TCGA-E7-A85H	BLCA	TCGA	DLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.5999
p.L435M	DO219018	BLCA	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.5999
p.N237D	TCGA-IB-7651	PAAD	TCGA	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation rewiring degron network	0.0833
p.N237D	DO46657	PAAD	ICGC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation rewiring degron network	0.0833
p.V225A	TCGA-XK-AAIW	PRAD	TCGA	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation altering degron motif	0.6936
p.V225A	DO51407	PRAD	ICGC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation altering degron motif	0.6936
p.K429Q	DO10172	COAD	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation substituting flanking lysine	0.3056
p.G440S	DO10020	COAD	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.2222
p.V425I	DO230312	COCA	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.N231Y	DO227686	COCA	ICGC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation rewiring degron network	0.25
p.G425V	DO229031	LICA	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.S233I	DO229009	LICA	ICGC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation rewiring degron network	0.1944
p.D434G	DO222354	LICA	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation altering degron motif	0.6087
p.I426R	DO228371	MALY	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation blocking ubiquitination signal	0.5556
p.I426R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation blocking ubiquitination signal	0.5556
p.I426R	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	DLR	DEG_APCC_TPR_1	434:436	Mutation blocking ubiquitination signal	0.5556
p.G445E	DO220886	MELA	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.G445E	DO47569	SKCM	ICGC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.0833
p.D427Y	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1389
p.D427Y	SIDM00318	Kidney Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1389
p.D427Y	SIDM01120	Other Solid Cancers	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1389
p.D427Y	SIDM01170	Ovarian Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.1389
p.L223P	SIDM00992	Thyroid Gland Carcinoma	GDSC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation altering degron motif	0.7582
p.L223P	ACH-000456	Thyroid Cancer	CCLE	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation altering degron motif	0.7582
p.L223P	BCPAP	thyroid	COSMIC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation altering degron motif	0.7582
p.K438I	SIDM00068	Colorectal Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.2778
p.K438I	GEO	large intestine	COSMIC	DLR	DEG_APCC_TPR_1	434:436	Mutation rewiring degron network	0.2778
p.K232Q	SIDM00118	Colorectal Carcinoma	GDSC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation substituting flanking lysine	0.3333
p.K232Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation substituting flanking lysine	0.3333
p.K232Q	HCC2998	large intestine	COSMIC	LNVFAD	LIG_APCC_ABBA_1	223:228	Mutation substituting flanking lysine	0.3333
p.G429V	SIDM00867	Glioblastoma	GDSC	DLR	DEG_APCC_TPR_1	434:436	Mutation substituting flanking lysine	0.3056
p.G429V	DBTRG-05MG	central nervous system	COSMIC	DLR	DEG_APCC_TPR_1	434:436	Mutation substituting flanking lysine	0.3056

Kaplan plot for STAMBPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAMBPL1

UniProt ID: Q96FJ0

Entrez ID: 57559

Protein name: AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAMBPL1 in