DegronMD

Uniprot ID: Q96FJ0

Source protein: AMSH-like protease

Source gene: STAMBPL1

Class: DEG_APCC_TPR_1

Location: 434:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8586

ASA_SCORE: 59.5

COIL: 0.6363

CONS_SCORE: 0.6669

DSS_SCORE: 0.4574

HELIX: 0.025

FCONS_SCORE: 1.4734

RIG_SCORE: 0.9204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V425L	TCGA-77-7465	LUSC	TCGA	DLR	DEG_APCC_TPR_1	0.0833
p.V425L	DO27699	LUSC	ICGC	DLR	DEG_APCC_TPR_1	0.0833
p.V432L	TCGA-B8-4148	KIRC	TCGA	DLR	DEG_APCC_TPR_1	0.2778
p.V432L	DO19168	KIRC	ICGC	DLR	DEG_APCC_TPR_1	0.2778
p.L424F	TCGA-BG-A220	UCEC	TCGA	DLR	DEG_APCC_TPR_1	0.0556
p.L424F	DO41784	UCEC	ICGC	DLR	DEG_APCC_TPR_1	0.0556
p.L435M	TCGA-E7-A85H	BLCA	TCGA	DLR	DEG_APCC_TPR_1	0.5999
p.L435M	DO219018	BLCA	ICGC	DLR	DEG_APCC_TPR_1	0.5999
p.K429Q	DO10172	COAD	ICGC	DLR	DEG_APCC_TPR_1	0.3056
p.G440S	DO10020	COAD	ICGC	DLR	DEG_APCC_TPR_1	0.2222
p.V425I	DO230312	COCA	ICGC	DLR	DEG_APCC_TPR_1	0.0833
p.G425V	DO229031	LICA	ICGC	DLR	DEG_APCC_TPR_1	0.0833
p.D434G	DO222354	LICA	ICGC	DLR	DEG_APCC_TPR_1	0.6087
p.I426R	DO228371	MALY	ICGC	DLR	DEG_APCC_TPR_1	0.5556
p.I426R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	DLR	DEG_APCC_TPR_1	0.5556
p.I426R	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	DLR	DEG_APCC_TPR_1	0.5556
p.G445E	DO220886	MELA	ICGC	DLR	DEG_APCC_TPR_1	0.0833
p.G445E	DO47569	SKCM	ICGC	DLR	DEG_APCC_TPR_1	0.0833
p.D427Y	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	0.1389
p.D427Y	SIDM00318	Kidney Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	0.1389
p.D427Y	SIDM01120	Other Solid Cancers	GDSC	DLR	DEG_APCC_TPR_1	0.1389
p.D427Y	SIDM01170	Ovarian Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	0.1389
p.K438I	SIDM00068	Colorectal Carcinoma	GDSC	DLR	DEG_APCC_TPR_1	0.2778
p.K438I	GEO	large_intestine	COSMIC	DLR	DEG_APCC_TPR_1	0.2778
p.G429V	SIDM00867	Glioblastoma	GDSC	DLR	DEG_APCC_TPR_1	0.3056
p.G429V	DBTRG-05MG	central_nervous_system	COSMIC	DLR	DEG_APCC_TPR_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54920	Alpha-soluble NSF attachment protein	DEG_APCC_TPR_1	293:295	DLR	APC,CDC20,FZR1	0.5982	More...
Q96FJ0	AMSH-like protease	DEG_APCC_TPR_1	434:436	DLR	APC,CDC20,FZR1	0.8586	More...
A8MWA4	Putative zinc finger protein 705EP	DEG_APCC_TPR_1	298:300	DLR	APC,CDC20,FZR1	0.6307	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons