DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DLR
Uniprot ID:
A8MWA4
Source protein:
Putative zinc finger protein 705EP
Source gene:
ZNF705EP
Class:
DEG_APCC_TPR_1
Location:
298:300
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6307
ASA_SCORE:
109.3
COIL:
0.8307
CONS_SCORE:
1
DSS_SCORE:
0.7073
HELIX:
0.1563
FCONS_SCORE:
1
RIG_SCORE:
0.7586
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ZNF705EP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P54920
Alpha-soluble NSF attachment protein
DEG_APCC_TPR_1
293:295
DLR
APC,CDC20,FZR1
0.5982
More...
Q96FJ0
AMSH-like protease
DEG_APCC_TPR_1
434:436
DLR
APC,CDC20,FZR1
0.8586
More...
A8MWA4
Putative zinc finger protein 705EP
DEG_APCC_TPR_1
298:300
DLR
APC,CDC20,FZR1
0.6307
More...