DegronMD

Uniprot ID: P54920

Source protein: Alpha-soluble NSF attachment protein

Source gene: NAPA

Class: DEG_APCC_TPR_1

Location: 293:295

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5982

ASA_SCORE: 91.6

COIL: 0.492

CONS_SCORE: 0.5039

DSS_SCORE: 0.8185

HELIX: 0.4927

FCONS_SCORE: 1.1169

RIG_SCORE: 0.7858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G289D	TCGA-D3-A2J6	SKCM	TCGA	DLR	DEG_APCC_TPR_1	0.2222
p.G289D	DO37901	SKCM	ICGC	DLR	DEG_APCC_TPR_1	0.2222
p.E291K	TCGA-DK-A3X1	BLCA	TCGA	DLR	DEG_APCC_TPR_1	0.2778
p.E291K	DO447	BLCA	ICGC	DLR	DEG_APCC_TPR_1	0.2778
p.R295C	ACH-000805	Skin Cancer	CCLE	DLR	DEG_APCC_TPR_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54920	Alpha-soluble NSF attachment protein	DEG_APCC_TPR_1	293:295	DLR	APC,CDC20,FZR1	0.5982	More...
Q96FJ0	AMSH-like protease	DEG_APCC_TPR_1	434:436	DLR	APC,CDC20,FZR1	0.8586	More...
A8MWA4	Putative zinc finger protein 705EP	DEG_APCC_TPR_1	298:300	DLR	APC,CDC20,FZR1	0.6307	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons