DegronMD

Uniprot ID: Q96ST8

Source protein: Centrosomal protein of 89 kDa

Source gene: CEP89

Class: DEG_SIAH_1

Location: 21:29

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8144

ASA_SCORE: 56.2778

COIL: 0.6072

CONS_SCORE: 0.3526

DSS_SCORE: 0.4513

HELIX: 0.2823

FCONS_SCORE: 0.8605

RIG_SCORE: 0.6723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I16T	TCGA-06-5416	GBM	TCGA	LPAASVAPK	DEG_SIAH_1	0.1944
p.I16T	DO10880	GBM	ICGC	LPAASVAPK	DEG_SIAH_1	0.1944
p.P22S	TCGA-77-A5G6	LUSC	TCGA	LPAASVAPK	DEG_SIAH_1	0.6752
p.P22S	DO50097	LUSC	ICGC	LPAASVAPK	DEG_SIAH_1	0.6752
p.R34H	TCGA-AA-3811	COAD	TCGA	LPAASVAPK	DEG_SIAH_1	0.1944
p.R34H	DO7962	COAD	ICGC	LPAASVAPK	DEG_SIAH_1	0.1944
p.R39H	TCGA-AJ-A3OK	UCEC	TCGA	LPAASVAPK	DEG_SIAH_1	0.0556
p.R39H	DO43602	UCEC	ICGC	LPAASVAPK	DEG_SIAH_1	0.0556
p.R39H	SIDM00683	Prostate Carcinoma	GDSC	LPAASVAPK	DEG_SIAH_1	0.0556
p.R39H	LNCaP-Clone-FGC	prostate	COSMIC	LPAASVAPK	DEG_SIAH_1	0.0556
p.F13V	TCGA-B5-A1MX	UCEC	TCGA	LPAASVAPK	DEG_SIAH_1	0.1111
p.F13V	DO41999	UCEC	ICGC	LPAASVAPK	DEG_SIAH_1	0.1111
p.P37S	TCGA-D3-A5GO	SKCM	TCGA	LPAASVAPK	DEG_SIAH_1	0.1111
p.P37S	DO47419	SKCM	ICGC	LPAASVAPK	DEG_SIAH_1	0.1111
p.G19C	TCGA-ER-A19H	SKCM	TCGA	LPAASVAPK	DEG_SIAH_1	0.2778
p.G19C	DO47299	SKCM	ICGC	LPAASVAPK	DEG_SIAH_1	0.2778
p.P37A	TCGA-XF-AAMG	BLCA	TCGA	LPAASVAPK	DEG_SIAH_1	0.1111
p.P37A	DO219049	BLCA	ICGC	LPAASVAPK	DEG_SIAH_1	0.1111
p.S25N	DO234352	ESAD	ICGC	LPAASVAPK	DEG_SIAH_1	0.5958
p.H18Y	DO233867	GACA	ICGC	LPAASVAPK	DEG_SIAH_1	0.25
p.P38L	DO231992	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	0.0833
p.H15N	DO229022	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	0.1667
p.H15N	DO229041	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	0.1667
p.P22L	SIDM00684	Glioblastoma	GDSC	LPAASVAPK	DEG_SIAH_1	0.7582
p.P22L	ACH-000595	Brain Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	0.7582
p.P22L	LN-229	central_nervous_system	COSMIC	LPAASVAPK	DEG_SIAH_1	0.7582
p.K29R	ACH-000973	Bladder Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	0.6126
p.K29R	639-V	urinary_tract	COSMIC	LPAASVAPK	DEG_SIAH_1	0.6126
p.A30T	ACH-002509	Skin Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ST8	Centrosomal protein of 89 kDa	DEG_SIAH_1	21:29	LPAASVAPK	SIAH1,SIAH2,SIAH3	0.8144	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPAASVAPK

Degron related mutations and impact score

Drug responses associated with CEP89 mutations

All proteins holding degron of LPAASVAPK