DegronMD - Q96ST8(CEP89)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I16T	TCGA-06-5416	GBM	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1944
p.I16T	DO10880	GBM	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1944
p.P22S	TCGA-77-A5G6	LUSC	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.6752
p.P22S	DO50097	LUSC	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.6752
p.V760I	TCGA-A6-6781	COAD	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.2222
p.V760I	DO8447	COAD	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.2222
p.R34H	TCGA-AA-3811	COAD	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1944
p.R34H	DO7962	COAD	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1944
p.R39H	TCGA-AJ-A3OK	UCEC	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.0556
p.R39H	DO43602	UCEC	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.0556
p.R39H	SIDM00683	Prostate Carcinoma	GDSC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.0556
p.R39H	LNCaP-Clone-FGC	prostate	COSMIC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.0556
p.A751D	TCGA-AX-A06F	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation altering degron motif	0.7793
p.A751D	DO41752	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation altering degron motif	0.7793
p.T739I	TCGA-AX-A06F	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation blocking phosphorylation signal	0.5278
p.T739I	DO41752	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation blocking phosphorylation signal	0.5278
p.V745M	TCGA-AX-A2HJ	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.25
p.V745M	DO42105	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.25
p.F13V	TCGA-B5-A1MX	UCEC	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.F13V	DO41999	UCEC	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.R750K	TCGA-CV-5442	HNSC	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation altering degron motif	0.6126
p.R750K	DO14678	HNSC	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation altering degron motif	0.6126
p.P37S	TCGA-D3-A5GO	SKCM	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.P37S	DO47419	SKCM	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.G19C	TCGA-ER-A19H	SKCM	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.2778
p.G19C	DO47299	SKCM	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.2778
p.Q762E	TCGA-P3-A5QF	HNSC	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.1667
p.Q762E	DO44439	HNSC	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.1667
p.P37A	TCGA-XF-AAMG	BLCA	TCGA	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.P37A	DO219049	BLCA	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1111
p.L757R	TCGA-XF-AAN0	BLCA	TCGA	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.3056
p.L757R	DO51941	BLCA	ICGC	NPRALVAPS	DEG_SIAH_1	748:756	Mutation rewiring degron network	0.3056
p.V398A	DO227999	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO229013	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO229016	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO229003	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO229005	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO234285	ESAD	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.V398A	DO229480	LAML	ICGC	VKENE	DEG_APCC_KENBOX_2	402:406	Mutation rewiring degron network	0.2222
p.S25N	DO234352	ESAD	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.5958
p.H18Y	DO233867	GACA	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.25
p.P38L	DO231992	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.0833
p.H15N	DO229022	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1667
p.H15N	DO229041	LICA	ICGC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.1667
p.P22L	SIDM00684	Glioblastoma	GDSC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.7582
p.P22L	ACH-000595	Brain Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.7582
p.P22L	LN-229	central nervous system	COSMIC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.7582
p.K29R	ACH-000973	Bladder Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.6126
p.K29R	639-V	urinary tract	COSMIC	LPAASVAPK	DEG_SIAH_1	21:29	Mutation altering degron motif	0.6126
p.A30T	ACH-002509	Skin Cancer	CCLE	LPAASVAPK	DEG_SIAH_1	21:29	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP89

UniProt ID: Q96ST8

Entrez ID: 84902

Protein name: Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP89 in