DegronMD

Uniprot ID: Q96ST8

Source protein: Centrosomal protein of 89 kDa

Source gene: CEP89

Class: DEG_SIAH_1

Location: 748:756

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5809

ASA_SCORE: 92.1889

COIL: 0.5116

CONS_SCORE: 0.1912

DSS_SCORE: 0.3963

HELIX: 0.4643

FCONS_SCORE: 0.7632

RIG_SCORE: 0.7747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V760I	TCGA-A6-6781	COAD	TCGA	NPRALVAPS	DEG_SIAH_1	0.2222
p.V760I	DO8447	COAD	ICGC	NPRALVAPS	DEG_SIAH_1	0.2222
p.A751D	TCGA-AX-A06F	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	0.7793
p.A751D	DO41752	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	0.7793
p.T739I	TCGA-AX-A06F	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	0.5278
p.T739I	DO41752	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	0.5278
p.V745M	TCGA-AX-A2HJ	UCEC	TCGA	NPRALVAPS	DEG_SIAH_1	0.25
p.V745M	DO42105	UCEC	ICGC	NPRALVAPS	DEG_SIAH_1	0.25
p.R750K	TCGA-CV-5442	HNSC	TCGA	NPRALVAPS	DEG_SIAH_1	0.6126
p.R750K	DO14678	HNSC	ICGC	NPRALVAPS	DEG_SIAH_1	0.6126
p.Q762E	TCGA-P3-A5QF	HNSC	TCGA	NPRALVAPS	DEG_SIAH_1	0.1667
p.Q762E	DO44439	HNSC	ICGC	NPRALVAPS	DEG_SIAH_1	0.1667
p.L757R	TCGA-XF-AAN0	BLCA	TCGA	NPRALVAPS	DEG_SIAH_1	0.3056
p.L757R	DO51941	BLCA	ICGC	NPRALVAPS	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ST8	Centrosomal protein of 89 kDa	DEG_SIAH_1	748:756	NPRALVAPS	SIAH1,SIAH2,SIAH3	0.5809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons