DegronMD

Uniprot ID: Q96ST8

Source protein: Centrosomal protein of 89 kDa

Source gene: CEP89

Class: DEG_APCC_KENBOX_2

Location: 402:406

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7849

ASA_SCORE: 102.22

COIL: 0.0188

CONS_SCORE: 0.6867

DSS_SCORE: 0.3721

HELIX: 0.9818

FCONS_SCORE: 1.3154

RIG_SCORE: 0.7551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V398A	DO227999	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO229013	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO229016	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO229003	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO229005	COCA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO234285	ESAD	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222
p.V398A	DO229480	LAML	ICGC	VKENE	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24278	Zinc finger and BTB domain-containing protein 25	DEG_APCC_KENBOX_2	302:306	VKENE	APC,CDC20,FZR1	0.9505	More...
Q96ST8	Centrosomal protein of 89 kDa	DEG_APCC_KENBOX_2	402:406	VKENE	APC,CDC20,FZR1	0.7849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons