DegronMD

Uniprot ID: P24278

Source protein: Zinc finger and BTB domain-containing protein 25

Source gene: ZBTB25

Class: DEG_APCC_KENBOX_2

Location: 302:306

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9505

ASA_SCORE: 104.14

COIL: 0.6502

CONS_SCORE: 0.6366

DSS_SCORE: 0.5507

HELIX: 0.1634

FCONS_SCORE: 1.2383

RIG_SCORE: 0.7072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R296S	TCGA-55-A4DG	LUAD	TCGA	VKENE	DEG_APCC_KENBOX_2	0.1667
p.R296S	DO26337	LUAD	ICGC	VKENE	DEG_APCC_KENBOX_2	0.1667
p.R296M	TCGA-A5-A0G2	UCEC	TCGA	VKENE	DEG_APCC_KENBOX_2	0.1667
p.R296M	DO41235	UCEC	ICGC	VKENE	DEG_APCC_KENBOX_2	0.1667
p.S299F	DO222542	MELA	ICGC	VKENE	DEG_APCC_KENBOX_2	0.25
p.L297F	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VKENE	DEG_APCC_KENBOX_2	0.1944
p.L297F	ACH-000995	Leukemia	CCLE	VKENE	DEG_APCC_KENBOX_2	0.1944
p.L297F	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VKENE	DEG_APCC_KENBOX_2	0.1944
p.R295H	SIDM00313	Hodgkin's Lymphoma	GDSC	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R295H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R295H	ACH-000702	Lymphoma	CCLE	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R295H	ACH-000888	Lung Cancer	CCLE	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R295H	NCI-H1793	lung	COSMIC	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R295H	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	VKENE	DEG_APCC_KENBOX_2	0.1389
p.R296W	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VKENE	DEG_APCC_KENBOX_2	0.1667
p.R296W	ACH-000825	Lung Cancer	CCLE	VKENE	DEG_APCC_KENBOX_2	0.1667
p.R296W	HOP-92	lung	COSMIC	VKENE	DEG_APCC_KENBOX_2	0.1667
p.C294Y	SIDM00014	Colorectal Carcinoma	GDSC	VKENE	DEG_APCC_KENBOX_2	0.1111
p.C294Y	LIM1215	large_intestine	COSMIC	VKENE	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24278	Zinc finger and BTB domain-containing protein 25	DEG_APCC_KENBOX_2	302:306	VKENE	APC,CDC20,FZR1	0.9505	More...
Q96ST8	Centrosomal protein of 89 kDa	DEG_APCC_KENBOX_2	402:406	VKENE	APC,CDC20,FZR1	0.7849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons