DegronMD

Uniprot ID: Q66K89

Source protein: Transcription factor E4F1

Source gene: E4F1

Class: DEG_SCF_FBW7_1

Location: 90:97

E3 ligase: FBXW7

DEGRON score: 0.9448

ASA_SCORE: 67.3125

COIL: 0.7775

CONS_SCORE: 0.3484

DSS_SCORE: 0.4673

HELIX: 0.1259

FCONS_SCORE: 0.9402

RIG_SCORE: 0.7128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P86S	TCGA-34-5232	LUSC	TCGA	LPATPATT	DEG_SCF_FBW7_1	0.2222
p.P86S	DO27168	LUSC	ICGC	LPATPATT	DEG_SCF_FBW7_1	0.2222
p.C82F	TCGA-38-4629	LUAD	TCGA	LPATPATT	DEG_SCF_FBW7_1	0.1111
p.C82F	DO23771	LUAD	ICGC	LPATPATT	DEG_SCF_FBW7_1	0.1111
p.A107V	TCGA-KQ-A41R	BLCA	TCGA	LPATPATT	DEG_SCF_FBW7_1	0.0556
p.A107V	DO223592	BLCA	ICGC	LPATPATT	DEG_SCF_FBW7_1	0.0556
p.R84W	DO50410	ESAD	ICGC	LPATPATT	DEG_SCF_FBW7_1	0.1667
p.R84Q	DO227567	ORCA	ICGC	LPATPATT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K89	Transcription factor E4F1	DEG_SCF_FBW7_1	90:97	LPATPATT	FBXW7	0.9448	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons