E4F1
UniProt ID: Q66K89
Entrez ID: 1877
Protein name: Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates t...
FUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; cell division [GO:0051301]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726...
cell cycle [GO:0007049]; cell division [GO:0051301]; DNA replication [GO:0006260]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle, embryonic [GO:0009794]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046...
cAMP response element binding [GO:0035497]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transferase activity [GO:0016740]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; spindle [GO:0005819]...
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; spindle [GO:0005819]
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E4F1
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Kaplan plot for E4F1 in
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*NOTE: the Kaplan plots were collected from OncoLnc