DegronMD

Uniprot ID: Q66K89

Source protein: Transcription factor E4F1

Source gene: E4F1

Class: DEG_SCF_FBW7_2

Location: 270:275

E3 ligase: FBXW7

DEGRON score: 0.905

ASA_SCORE: 60.75

COIL: 0.8138

CONS_SCORE: 0.9661

DSS_SCORE: 0.262

HELIX: 0.1605

FCONS_SCORE: 1.1425

RIG_SCORE: 0.8093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R278C	TCGA-AP-A1DK	UCEC	TCGA	LTPCTE	DEG_SCF_FBW7_2	0.25
p.R278C	DO42033	UCEC	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.25
p.S260L	TCGA-AX-A3G9	UCEC	TCGA	LTPCTE	DEG_SCF_FBW7_2	0.5
p.S260L	DO41241	UCEC	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.5
p.T271I	TCGA-D1-A103	UCEC	TCGA	LTPCTE	DEG_SCF_FBW7_2	0.7078
p.T271I	DO42312	UCEC	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.7078
p.S269P	TCGA-VQ-A8P2	STAD	TCGA	LTPCTE	DEG_SCF_FBW7_2	0.75
p.S269P	DO51761	STAD	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.75
p.I277M	DO225215	BRCA	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.2778
p.I277M	DO227836	BRCA	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.2778
p.C273Y	DO234219	ESAD	ICGC	LTPCTE	DEG_SCF_FBW7_2	0.5976
p.A262T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LTPCTE	DEG_SCF_FBW7_2	0.1111
p.A262T	ACH-002059	Leukemia	CCLE	LTPCTE	DEG_SCF_FBW7_2	0.1111
p.A262T	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTPCTE	DEG_SCF_FBW7_2	0.1111
p.R278H	SIDM00379	Glioma	GDSC	LTPCTE	DEG_SCF_FBW7_2	0.25
p.R278H	ACH-001991	Primary	CCLE	LTPCTE	DEG_SCF_FBW7_2	0.25
p.R278H	ACH-002304	Brain Cancer	CCLE	LTPCTE	DEG_SCF_FBW7_2	0.25
p.R278H	SK-MG-1	central_nervous_system	COSMIC	LTPCTE	DEG_SCF_FBW7_2	0.25
p.D284G	SIDM00217	Colorectal Carcinoma	GDSC	LTPCTE	DEG_SCF_FBW7_2	0.0833
p.D284G	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPCTE	DEG_SCF_FBW7_2	0.0833
p.D284G	SNU-1040	large_intestine	COSMIC	LTPCTE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q66K89	Transcription factor E4F1	DEG_SCF_FBW7_2	270:275	LTPCTE	FBXW7	0.905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons