DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LPATPHSS
Uniprot ID:
Q9H6K5
Source protein:
Proline-rich protein 36
Source gene:
PRR36
Class:
DEG_SCF_FBW7_1
Location:
353:360
E3 ligase:
FBXW7
DEGRON score:
0.9685
ASA_SCORE:
87.5375
COIL:
0.9585
CONS_SCORE:
0
DSS_SCORE:
0.6551
HELIX:
0.0216
FCONS_SCORE:
0
RIG_SCORE:
0.582
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PRR36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPATPHSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6K5
Proline-rich protein 36
DEG_SCF_FBW7_1
353:360
LPATPHSS
FBXW7
0.9685
More...