DegronMD

Uniprot ID: Q9H211

Source protein: DNA replication factor Cdt1

Source gene: CDT1

Class: DEG_SCF_FBW7_1

Location: 399:406

E3 ligase: FBXW7

DEGRON score: 0.9573

ASA_SCORE: 88.5625

COIL: 0.9636

CONS_SCORE: 0.3365

DSS_SCORE: 0.7581

HELIX: 0.0102

FCONS_SCORE: 0.8287

RIG_SCORE: 0.5419

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P395T	TCGA-AB-2849	LAML	TCGA	LPATPPAT	DEG_SCF_FBW7_1	0.2222
p.P395T	DO21403	LAML	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.2222
p.A409T	TCGA-EO-A22U	UCEC	TCGA	LPATPPAT	DEG_SCF_FBW7_1	0.25
p.A409T	DO43755	UCEC	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.25
p.P404A	TCGA-UY-A9PB	BLCA	TCGA	LPATPPAT	DEG_SCF_FBW7_1	0.6392
p.P404A	DO219041	BLCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.6392
p.T406P	DO48360	BLCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T406P	DO229453	SKCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.P389H	DO233941	GACA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.0556
p.A405S	DO229006	LICA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	0.6477
p.R396K	SIDM00251	Gastric Carcinoma	GDSC	LPATPPAT	DEG_SCF_FBW7_1	0.25
p.R396K	ACH-000949	Gastric Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.25
p.R396K	TGBC11TKB	stomach	COSMIC	LPATPPAT	DEG_SCF_FBW7_1	0.25
p.P395S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LPATPPAT	DEG_SCF_FBW7_1	0.2222
p.P395S	ACH-000925	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.2222
p.T402P	ACH-000108	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000155	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000190	Unknown	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000197	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000207	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000308	Ovarian Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000472	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000727	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000786	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000802	Bladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000832	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000960	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-000986	Colon/Colorectal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-001125	Brain Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-001364	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002090	Kidney Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002117	Bone Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002156	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002200	Skin Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002209	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002213	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002215	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002220	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002232	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002234	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002235	Bladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002236	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002261	Neuroblastoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002262	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002280	Neuroblastoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002288	Embryonal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002312	Gallbladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002344	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002345	Colon/Colorectal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002354	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002357	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002361	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002369	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142
p.T402P	ACH-002371	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	0.8142

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPATPPAT

Degron related mutations and impact score

Drug responses associated with CDT1 mutations

All proteins holding degron of LPATPPAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H211	DNA replication factor Cdt1	DEG_SCF_FBW7_1	399:406	LPATPPAT	FBXW7	0.9573	More...