DegronMD - Q9H211(CDT1)

FUNCTION: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phas... View more >>

GO - Biological processes (BP): attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; deactivation of mitotic spindle assembly checkpoint [GO:1902426]; DNA replication checkpoint signaling [GO:0000076]; DNA replication preinitiation complex assembly... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]

GO - Cellular component (CC): cytosol [GO:0005829]; kinetochore [GO:0000776]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T406P	DO48360	BLCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T406P	DO229453	SKCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000108	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000155	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000190	Unknown	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000197	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000207	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000308	Ovarian Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000472	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000727	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000786	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000802	Bladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000832	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000960	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000986	Colon/Colorectal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-001125	Brain Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-001364	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002090	Kidney Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002117	Bone Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002156	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142

Showing 1 to 20 of 70 entries

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Kaplan plot for CDT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDT1

UniProt ID: Q9H211

Entrez ID: 81620

Protein name: DNA replication factor Cdt1 (Double parked homolog) (DUP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDT1 in