DegronMD - Q9H211(CDT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P395T	TCGA-AB-2849	LAML	TCGA	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.2222
p.P395T	DO21403	LAML	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.2222
p.A409T	TCGA-EO-A22U	UCEC	TCGA	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.25
p.A409T	DO43755	UCEC	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.25
p.I20M	TCGA-GC-A3YS	BLCA	TCGA	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	TCGA-GC-A3YS	BLCA	TCGA	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO850	BLCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO850	BLCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO224990	BRCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO224990	BRCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO224594	LUSC	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	DO224594	LUSC	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	SIDM00905	Cervical Carcinoma	GDSC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	SIDM00905	Cervical Carcinoma	GDSC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	ACH-001334	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	ACH-001334	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.I20M	ACH-001335	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1944
p.I20M	ACH-001335	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1944
p.P404A	TCGA-UY-A9PB	BLCA	TCGA	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.6392
p.P404A	DO219041	BLCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.6392
p.T406P	DO48360	BLCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T406P	DO229453	SKCA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.P389H	DO233941	GACA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.0556
p.A405S	DO229006	LICA	ICGC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.6477
p.A21V	DO229221	THCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	3:15	Mutation rewiring degron network	0.1667
p.A21V	DO229221	THCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	3:15	Mutation rewiring degron network	0.1667
p.R396K	SIDM00251	Gastric Carcinoma	GDSC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.25
p.R396K	ACH-000949	Gastric Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.25
p.R396K	TGBC11TKB	stomach	COSMIC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.25
p.P395S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.2222
p.P395S	ACH-000925	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation rewiring degron network	0.2222
p.T402P	ACH-000108	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000155	Pancreatic Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000190	Unknown	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000197	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000207	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000308	Ovarian Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000472	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000727	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000786	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000802	Bladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000832	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000960	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-000986	Colon/Colorectal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-001125	Brain Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-001364	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002090	Kidney Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002117	Bone Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002156	Lung Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002200	Skin Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002209	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002213	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002215	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002220	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002232	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002234	Head and Neck Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002235	Bladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002236	Lymphoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002261	Neuroblastoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002262	Leukemia	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002280	Neuroblastoma	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002288	Embryonal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002312	Gallbladder Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002344	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002345	Colon/Colorectal Cancer	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002354	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002357	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002361	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002369	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142
p.T402P	ACH-002371	Non-Cancerous	CCLE	LPATPPAT	DEG_SCF_FBW7_1	399:406	Mutation altering degron motif	0.8142

Kaplan plot for CDT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDT1

UniProt ID: Q9H211

Entrez ID: 81620

Protein name: DNA replication factor Cdt1 (Double parked homolog) (DUP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDT1 in