DegronMD

Uniprot ID: Q9H211

Source protein: DNA replication factor Cdt1

Source gene: CDT1

Class: DEG_CRL4_CDT2_1

Location: 3:15

E3 ligase: DTL

DEGRON score: 0.995

ASA_SCORE: 100.3692

COIL: 0.5678

CONS_SCORE: 0.4835

DSS_SCORE: 0.7453

HELIX: 0.3863

FCONS_SCORE: 1.4378

RIG_SCORE: 0.7474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I20M	TCGA-GC-A3YS	BLCA	TCGA	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	TCGA-GC-A3YS	BLCA	TCGA	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	DO850	BLCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	DO850	BLCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	DO224990	BRCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	DO224990	BRCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	DO224594	LUSC	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	DO224594	LUSC	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	SIDM00905	Cervical Carcinoma	GDSC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	SIDM00905	Cervical Carcinoma	GDSC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	ACH-001334	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	ACH-001334	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.I20M	ACH-001335	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1944
p.I20M	ACH-001335	Cervical Cancer	CCLE	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1944
p.A21V	DO229221	THCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_1	0.1667
p.A21V	DO229221	THCA	ICGC	QRRVTDFFARRRP	DEG_CRL4_CDT2_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons