DegronMD

Uniprot ID: Q9NRL2

Source protein: Bromodomain adjacent to zinc finger domain protein 1A

Source gene: BAZ1A

Class: DEG_SCF_SKP2-CKS1_1

Location: 410:417

E3 ligase: SKP2,CSK1

DEGRON score: 0.8114

ASA_SCORE: 76.775

COIL: 0.8914

CONS_SCORE: 0.3939

DSS_SCORE: 0.4816

HELIX: 0.0189

FCONS_SCORE: 0.8286

RIG_SCORE: 0.7259

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D406A	TCGA-D7-A6EY	STAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D406A	DO50118	STAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P411S	TCGA-EE-A29E	SKCM	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.5641
p.P411S	DO37831	SKCM	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.5641
p.E412K	TCGA-EY-A2OM	UCEC	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E412K	DO43025	UCEC	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.7022
p.P421S	TCGA-G4-6588	COAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.P421S	DO10140	COAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T414K	TCGA-HU-A4H4	STAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.7306
p.T414K	DO229037	LICA	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.7306
p.T414K	DO47721	STAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.7306
p.P413T	DO228985	LICA	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRL2	Bromodomain adjacent to zinc finger domain protein 1A	DEG_SCF_SKP2-CKS1_1	410:417	LPEPTPVK	SKP2,CSK1	0.8114	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons