DegronMD - Q9NRL2(BAZ1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1182F	TCGA-AG-A002	READ	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.6981
p.D406A	TCGA-D7-A6EY	STAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.1944
p.D406A	TCGA-D7-A6EY	STAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.2222
p.D406A	DO50118	STAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.1944
p.D406A	DO50118	STAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.2222
p.R1179Q	TCGA-DU-6392	LGG	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.7329
p.R1179Q	DO22237	LGG	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.7329
p.P411S	TCGA-EE-A29E	SKCM	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.6752
p.P411S	TCGA-EE-A29E	SKCM	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.5641
p.P411S	DO37831	SKCM	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.6752
p.P411S	DO37831	SKCM	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.5641
p.H1174Y	TCGA-EE-A29M	SKCM	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.2222
p.H1174Y	DO37404	SKCM	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.2222
p.R1171S	TCGA-EE-A2GE	SKCM	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.1389
p.R1171S	DO38016	SKCM	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.1389
p.E412K	TCGA-EY-A2OM	UCEC	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.591
p.E412K	TCGA-EY-A2OM	UCEC	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.7022
p.E412K	DO43025	UCEC	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.591
p.E412K	DO43025	UCEC	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.7022
p.P421S	TCGA-G4-6588	COAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.25
p.P421S	TCGA-G4-6588	COAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.2222
p.P421S	DO10140	COAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.25
p.P421S	DO10140	COAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.2222
p.T414K	TCGA-HU-A4H4	STAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.7306
p.T414K	TCGA-HU-A4H4	STAD	TCGA	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.7306
p.T414K	DO229037	LICA	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.7306
p.T414K	DO229037	LICA	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.7306
p.T414K	DO47721	STAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.7306
p.T414K	DO47721	STAD	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.7306
p.P413T	DO228985	LICA	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation altering degron motif	0.5919
p.P413T	DO228985	LICA	ICGC	LPEPTPVK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation altering degron motif	0.5919
p.P1186T	DO229022	LICA	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.5919
p.R1196Q	SIDM02048	Colorectal Carcinoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.0556
p.A428G	SIDM00392	Melanoma	GDSC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428G	ACH-000810	Skin Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428G	SK-MEL-30	skin	COSMIC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428V	SIDM00660	Colorectal Carcinoma	GDSC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428V	ACH-000985	Colon/Colorectal Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428V	ACH-001786	Colon/Colorectal Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.A428V	LS-411N	large intestine	COSMIC	PEPTPVKT	DEG_SCF_FBW7_1	411:418	Mutation rewiring degron network	0.0556
p.T1184A	SIDM00337	Melanoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.6028
p.T1184A	MEL-HO	skin	COSMIC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation altering degron motif	0.6028
p.P1193S	SIDM00901	Endometrial Carcinoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.1389
p.P1193S	ACH-000940	Endometrial/Uterine Cancer	CCLE	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.1389
p.P1193S	AN3-CA	endometrium	COSMIC	VRPKLKTVP	DEG_APCC_DBOX_1	1178:1186	Mutation rewiring degron network	0.1389

Kaplan plot for BAZ1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAZ1A

UniProt ID: Q9NRL2

Entrez ID: 11177

Protein name: Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAZ1A in