DegronMD

Uniprot ID: Q9NRL2

Source protein: Bromodomain adjacent to zinc finger domain protein 1A

Source gene: BAZ1A

Class: DEG_APCC_DBOX_1

Location: 1178:1186

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5947

ASA_SCORE: 69.2

COIL: 0.9147

CONS_SCORE: 0.4055

DSS_SCORE: 0.1111

HELIX: 0.0214

FCONS_SCORE: 0.9729

RIG_SCORE: 0.7747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1182F	TCGA-AG-A002	READ	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	0.6981
p.R1179Q	TCGA-DU-6392	LGG	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	0.7329
p.R1179Q	DO22237	LGG	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	0.7329
p.H1174Y	TCGA-EE-A29M	SKCM	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	0.2222
p.H1174Y	DO37404	SKCM	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	0.2222
p.R1171S	TCGA-EE-A2GE	SKCM	TCGA	VRPKLKTVP	DEG_APCC_DBOX_1	0.1389
p.R1171S	DO38016	SKCM	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	0.1389
p.P1186T	DO229022	LICA	ICGC	VRPKLKTVP	DEG_APCC_DBOX_1	0.5919
p.R1196Q	SIDM02048	Colorectal Carcinoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	0.0556
p.T1184A	SIDM00337	Melanoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	0.6028
p.T1184A	MEL-HO	skin	COSMIC	VRPKLKTVP	DEG_APCC_DBOX_1	0.6028
p.P1193S	SIDM00901	Endometrial Carcinoma	GDSC	VRPKLKTVP	DEG_APCC_DBOX_1	0.1389
p.P1193S	ACH-000940	Endometrial/Uterine Cancer	CCLE	VRPKLKTVP	DEG_APCC_DBOX_1	0.1389
p.P1193S	AN3-CA	endometrium	COSMIC	VRPKLKTVP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRL2	Bromodomain adjacent to zinc finger domain protein 1A	DEG_APCC_DBOX_1	1178:1186	VRPKLKTVP	APC,CDC20,FZR1	0.5947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons