DegronMD

Uniprot ID: Q9NRL2

Source protein: Bromodomain adjacent to zinc finger domain protein 1A

Source gene: BAZ1A

Class: DEG_SCF_FBW7_1

Location: 411:418

E3 ligase: FBXW7

DEGRON score: 0.8354

ASA_SCORE: 76.6

COIL: 0.8793

CONS_SCORE: 0.3742

DSS_SCORE: 0.4866

HELIX: 0.0218

FCONS_SCORE: 0.7738

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D406A	TCGA-D7-A6EY	STAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	0.1944
p.D406A	DO50118	STAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.1944
p.P411S	TCGA-EE-A29E	SKCM	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	0.6752
p.P411S	DO37831	SKCM	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.6752
p.E412K	TCGA-EY-A2OM	UCEC	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	0.591
p.E412K	DO43025	UCEC	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.591
p.P421S	TCGA-G4-6588	COAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	0.25
p.P421S	DO10140	COAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.25
p.T414K	TCGA-HU-A4H4	STAD	TCGA	PEPTPVKT	DEG_SCF_FBW7_1	0.7306
p.T414K	DO229037	LICA	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.7306
p.T414K	DO47721	STAD	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.7306
p.P413T	DO228985	LICA	ICGC	PEPTPVKT	DEG_SCF_FBW7_1	0.5919
p.A428G	SIDM00392	Melanoma	GDSC	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428G	ACH-000810	Skin Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428G	SK-MEL-30	skin	COSMIC	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428V	SIDM00660	Colorectal Carcinoma	GDSC	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428V	ACH-000985	Colon/Colorectal Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428V	ACH-001786	Colon/Colorectal Cancer	CCLE	PEPTPVKT	DEG_SCF_FBW7_1	0.0556
p.A428V	LS-411N	large_intestine	COSMIC	PEPTPVKT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRL2	Bromodomain adjacent to zinc finger domain protein 1A	DEG_SCF_FBW7_1	411:418	PEPTPVKT	FBXW7	0.8354	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons