DegronMD

Uniprot ID: Q14244

Source protein: Ensconsin

Source gene: MAP7

Class: DEG_SCF_FBW7_1

Location: 339:346

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 92.3375

COIL: 0.9614

CONS_SCORE: 0.5466

DSS_SCORE: 0.7059

HELIX: 0.0124

FCONS_SCORE: 1.1235

RIG_SCORE: 0.5271

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R333Q	TCGA-44-A47B	LUAD	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.1667
p.A347P	TCGA-55-8299	LUAD	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.75
p.A347P	DO25927	LUAD	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.75
p.S355F	TCGA-78-7155	LUAD	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.1944
p.S355F	DO23590	LUAD	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.1944
p.R348C	TCGA-D1-A17Q	UCEC	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.2778
p.R348C	TCGA-EO-A22R	UCEC	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.2778
p.R348C	DO41903	UCEC	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.2778
p.R348C	DO42713	UCEC	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.2778
p.R334M	TCGA-DF-A2KN	UCEC	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.R334M	DO223282	UCEC	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.R334M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.R333L	TCGA-E6-A1LX	UCEC	TCGA	LPGTPRPT	DEG_SCF_FBW7_1	0.1667
p.R333L	NCI-H345	lung	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.1667
p.A343E	DO229015	LICA	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.7701
p.P338S	DO222653	MELA	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.3056
p.S339F	DO219871	SKCA	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.7982
p.S339F	DO229453	SKCA	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.7982
p.P343L	DO42312	UCEC	ICGC	LPGTPRPT	DEG_SCF_FBW7_1	0.7582
p.A351T	SIDM01289	Esophageal Carcinoma	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.1944
p.R342M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.8632
p.R342M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.8632
p.A343V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.6936
p.A343V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.6936
p.R356C	SIDM00277	Acute Myeloid Leukemia	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.0556
p.R356C	SIDM01159	Other Sarcomas	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.0556
p.R356C	SIDM00783	Colorectal Carcinoma	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.0556
p.R341L	SIDM00719	Small Cell Lung Carcinoma	GDSC	LPGTPRPT	DEG_SCF_FBW7_1	0.8428
p.R341L	NCI-H345	lung	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.8428
p.G341D	ACH-000272	Kidney Cancer	CCLE	LPGTPRPT	DEG_SCF_FBW7_1	0.6087
p.D329Y	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.0556
p.E346K	PANC-08-13	pancreas	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.7022
p.A335V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.6667
p.Q345P	AGS	stomach	COSMIC	LPGTPRPT	DEG_SCF_FBW7_1	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPGTPRPT

Degron related mutations and impact score

Drug responses associated with MAP7 mutations

All proteins holding degron of LPGTPRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14244	Ensconsin	DEG_SCF_FBW7_1	339:346	LPGTPRPT	FBXW7	0.9937	More...