DegronMD

Uniprot ID: Q7Z406

Source protein: Myosin-14

Source gene: MYH14

Class: LIG_APCC_ABBA_1

Location: 151:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8356

ASA_SCORE: 49.2667

COIL: 0.761

CONS_SCORE: 0.5826

DSS_SCORE: 0.0389

HELIX: 0.1797

FCONS_SCORE: 1.0375

RIG_SCORE: 0.9505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y154C	TCGA-HT-7609	LGG	TCGA	LPIYTE	LIG_APCC_ABBA_1	0.8198
p.Y154C	DO22732	LGG	ICGC	LPIYTE	LIG_APCC_ABBA_1	0.8198
p.R150Q	SNU-175	large_intestine	COSMIC	LPIYTE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z406	Myosin-14	LIG_APCC_ABBA_1	151:156	LPIYTE	APC,CDC20,FZR1	0.8356	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons