DegronMD - Q7Z406(MYH14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1536C	TCGA-AB-2936	LAML	TCGA	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation blocking phosphorylation signal	0.7222
p.V1522A	TCGA-BG-A222	UCEC	TCGA	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2222
p.R1524W	TCGA-D1-A17Q	UCEC	TCGA	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2778
p.R1524W	SIDM01218	Other Solid Cancers	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2778
p.R1524W	ACH-001530	Endometrial/Uterine Cancer	CCLE	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2778
p.R1524W	JEG-3	placenta	COSMIC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2778
p.R1524L	TCGA-FS-A1Z0	SKCM	TCGA	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.2778
p.Y154C	TCGA-HT-7609	LGG	TCGA	LPIYTE	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.8198
p.Y154C	DO22732	LGG	ICGC	LPIYTE	LIG_APCC_ABBA_1	151:156	Mutation altering degron motif	0.8198
p.R1531Q	TCGA-Z2-A8RT	SKCM	TCGA	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.7329
p.R1516W	DO234181	ESAD	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.0556
p.R1516W	DO41903	UCEC	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.0556
p.G1528C	DO21349	LAML	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.76
p.R1531L	DO228948	LICA	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8428
p.V1526L	DO228974	LICA	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.6765
p.R1516L	DO37431	SKCM	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.0556
p.R1523Q	DO51301	SKCM	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.25
p.T1539R	DO43779	UCEC	ICGC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation rewiring degron network	0.1944
p.R1529C	SIDM00819	Kidney Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8301
p.R1529C	ACH-002189	Kidney Cancer	CCLE	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8301
p.R1529C	RCC-FG2	kidney	COSMIC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8301
p.R1529H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8244
p.R1529H	SIDM00720	Mesothelioma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8244
p.R1529H	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8244
p.R1531W	SIDM01608	Endometrial Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	1526:1534	Mutation altering degron motif	0.8634
p.R150Q	SNU-175	large intestine	COSMIC	LPIYTE	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.3056

Kaplan plot for MYH14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYH14

UniProt ID: Q7Z406

Entrez ID: 79784

Protein name: Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYH14 in