DegronMD

Uniprot ID: Q7Z406

Source protein: Myosin-14

Source gene: MYH14

Class: DEG_APCC_DBOX_1

Location: 1526:1534

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9256

ASA_SCORE: 84.7778

COIL: 0.0362

CONS_SCORE: 0.4155

DSS_SCORE: 0.3559

HELIX: 0.9639

FCONS_SCORE: 1.2167

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1536C	TCGA-AB-2936	LAML	TCGA	LRAELEALL	DEG_APCC_DBOX_1	0.7222
p.V1522A	TCGA-BG-A222	UCEC	TCGA	LRAELEALL	DEG_APCC_DBOX_1	0.2222
p.R1524W	TCGA-D1-A17Q	UCEC	TCGA	LRAELEALL	DEG_APCC_DBOX_1	0.2778
p.R1524W	SIDM01218	Other Solid Cancers	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.2778
p.R1524W	ACH-001530	Endometrial/Uterine Cancer	CCLE	LRAELEALL	DEG_APCC_DBOX_1	0.2778
p.R1524W	JEG-3	placenta	COSMIC	LRAELEALL	DEG_APCC_DBOX_1	0.2778
p.R1524L	TCGA-FS-A1Z0	SKCM	TCGA	LRAELEALL	DEG_APCC_DBOX_1	0.2778
p.R1531Q	TCGA-Z2-A8RT	SKCM	TCGA	LRAELEALL	DEG_APCC_DBOX_1	0.7329
p.R1516W	DO234181	ESAD	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.0556
p.R1516W	DO41903	UCEC	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.0556
p.G1528C	DO21349	LAML	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.76
p.R1531L	DO228948	LICA	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.8428
p.V1526L	DO228974	LICA	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.6765
p.R1516L	DO37431	SKCM	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.0556
p.R1523Q	DO51301	SKCM	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.25
p.T1539R	DO43779	UCEC	ICGC	LRAELEALL	DEG_APCC_DBOX_1	0.1944
p.R1529C	SIDM00819	Kidney Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.8301
p.R1529C	ACH-002189	Kidney Cancer	CCLE	LRAELEALL	DEG_APCC_DBOX_1	0.8301
p.R1529C	RCC-FG2	kidney	COSMIC	LRAELEALL	DEG_APCC_DBOX_1	0.8301
p.R1529H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.8244
p.R1529H	SIDM00720	Mesothelioma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.8244
p.R1529H	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.8244
p.R1531W	SIDM01608	Endometrial Carcinoma	GDSC	LRAELEALL	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z406	Myosin-14	DEG_APCC_DBOX_1	1526:1534	LRAELEALL	APC,CDC20,FZR1	0.9256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons