DegronMD

Uniprot ID: Q96MH2

Source protein: Protein HEXIM2

Source gene: HEXIM2

Class: DEG_SCF_FBW7_2

Location: 43:50

E3 ligase: FBXW7

DEGRON score: 0.6394

ASA_SCORE: 93.2

COIL: 0.8971

CONS_SCORE: 0.2686

DSS_SCORE: 0.7883

HELIX: 0.0745

FCONS_SCORE: 0.8409

RIG_SCORE: 0.6018

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D57Y	TCGA-06-5416	GBM	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.D57Y	DO10880	GBM	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R48Q	TCGA-61-1995	OV	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.6218
p.R48Q	DO29116	OV	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.6218
p.S39Y	TCGA-A5-A0G2	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.6667
p.S39Y	DO41235	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.6667
p.L45M	TCGA-A5-A0G2	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.5999
p.L45M	DO41235	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.5999
p.D57V	TCGA-A6-6652	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.D57V	DO7946	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R48W	TCGA-AA-3845	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.7523
p.R48W	DO10020	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.7523
p.R36H	TCGA-AG-A02N	READ	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	TCGA-CM-6171	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	TCGA-D1-A1NZ	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	DO8151	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	DO37146	READ	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	DO41536	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	SIDM00783	Colorectal Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	ACH-000971	Colon/Colorectal Cancer	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.R36H	HCT-116	large_intestine	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	0.1389
p.A59T	TCGA-DI-A1BU	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.A59T	DO42023	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.D55N	TCGA-FS-A1YW	SKCM	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1944
p.D55N	DO37734	SKCM	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1944
p.E56K	TCGA-UF-A71B	HNSC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	0.1667
p.E56K	DO52107	HNSC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.1667
p.E56K	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.1667
p.E56K	ACH-000981	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.1667
p.E56K	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	0.1667
p.E54Q	DO224751	BRCA	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.2222
p.P44S	DO231641	LINC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	0.5641
p.L43M	SIDM01314	Colorectal Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.5999
p.A59V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.A59V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.A59V	ACH-000995	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.A59V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	0.0833
p.T46S	SIDM00410	Other Blood Cancers	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.8227
p.T46S	ACH-002317	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.8227
p.T46S	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	0.8227
p.G60V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	0.0556
p.G60V	ACH-000888	Lung Cancer	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.0556
p.G60V	NCI-H1793	lung	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	0.0556
p.P34A	ACH-000170	Non-Cancerous	CCLE	LPLTPRME	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPLTPRME

Degron related mutations and impact score

Drug responses associated with HEXIM2 mutations

All proteins holding degron of LPLTPRME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MH2	Protein HEXIM2	DEG_SCF_FBW7_2	43:50	LPLTPRME	FBXW7	0.6394	More...