DegronMD - Q96MH2(HEXIM2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D57Y	TCGA-06-5416	GBM	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.D57Y	DO10880	GBM	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R48Q	TCGA-61-1995	OV	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.6218
p.R48Q	DO29116	OV	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.6218
p.S39Y	TCGA-A5-A0G2	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation blocking phosphorylation signal	0.6667
p.S39Y	DO41235	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation blocking phosphorylation signal	0.6667
p.L45M	TCGA-A5-A0G2	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.5999
p.L45M	DO41235	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.5999
p.D57V	TCGA-A6-6652	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.D57V	DO7946	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R48W	TCGA-AA-3845	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.7523
p.R48W	DO10020	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.7523
p.R36H	TCGA-AG-A02N	READ	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	TCGA-CM-6171	COAD	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	TCGA-D1-A1NZ	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	DO8151	COAD	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	DO37146	READ	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	DO41536	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	SIDM00783	Colorectal Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	ACH-000971	Colon/Colorectal Cancer	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.R36H	HCT-116	large intestine	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1389
p.A59T	TCGA-DI-A1BU	UCEC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.A59T	DO42023	UCEC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.D55N	TCGA-FS-A1YW	SKCM	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1944
p.D55N	DO37734	SKCM	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1944
p.E56K	TCGA-UF-A71B	HNSC	TCGA	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1667
p.E56K	DO52107	HNSC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1667
p.E56K	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1667
p.E56K	ACH-000981	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1667
p.E56K	DND-41	haematopoietic and lymphoid tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.1667
p.E54Q	DO224751	BRCA	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.2222
p.P44S	DO231641	LINC	ICGC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.5641
p.L43M	SIDM01314	Colorectal Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.5999
p.A59V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.A59V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.A59V	ACH-000995	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.A59V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833
p.P5L	SIDM01134	Small Cell Lung Carcinoma	GDSC	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.7582
p.P5L	ACH-000292	Lung Cancer	CCLE	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.7582
p.P5L	NCI-H841	lung	COSMIC	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.7582
p.E13K	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1944
p.E13K	ACH-000785	Lung Cancer	CCLE	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1944
p.E13K	NCI-H2126	lung	COSMIC	MMATPNQT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1944
p.T46S	SIDM00410	Other Blood Cancers	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.8227
p.T46S	ACH-002317	Leukemia	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.8227
p.T46S	YT	haematopoietic and lymphoid tissue	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation altering degron motif	0.8227
p.G60V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0556
p.G60V	ACH-000888	Lung Cancer	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0556
p.G60V	NCI-H1793	lung	COSMIC	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0556
p.P34A	ACH-000170	Non-Cancerous	CCLE	LPLTPRME	DEG_SCF_FBW7_2	43:50	Mutation rewiring degron network	0.0833

Kaplan plot for HEXIM2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEXIM2

UniProt ID: Q96MH2

Entrez ID: 124790

Protein name: Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HEXIM2 in