DegronMD

Uniprot ID: Q96MH2

Source protein: Protein HEXIM2

Source gene: HEXIM2

Class: DEG_SCF_FBW7_1

Location: 1:8

E3 ligase: FBXW7

DEGRON score: 0.9863

ASA_SCORE: 100.6875

COIL: 0.8185

CONS_SCORE: 0.3105

DSS_SCORE: 0.8511

HELIX: 0.128

FCONS_SCORE: 1.0859

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P5L	SIDM01134	Small Cell Lung Carcinoma	GDSC	MMATPNQT	DEG_SCF_FBW7_1	0.7582
p.P5L	ACH-000292	Lung Cancer	CCLE	MMATPNQT	DEG_SCF_FBW7_1	0.7582
p.P5L	NCI-H841	lung	COSMIC	MMATPNQT	DEG_SCF_FBW7_1	0.7582
p.E13K	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	MMATPNQT	DEG_SCF_FBW7_1	0.1944
p.E13K	ACH-000785	Lung Cancer	CCLE	MMATPNQT	DEG_SCF_FBW7_1	0.1944
p.E13K	NCI-H2126	lung	COSMIC	MMATPNQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MH2	Protein HEXIM2	DEG_SCF_FBW7_1	1:8	MMATPNQT	FBXW7	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons